印度古吉拉特邦东部地区爆发钱迪普拉病毒脑炎疫情。

An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India.

作者信息

Chadha Mandeep S, Arankalle Vidya A, Jadi Ramesh S, Joshi Manohar V, Thakare Jyotsna P, Mahadev P V M, Mishra A C

机构信息

National Institute of Virology 20-A, Dr. Ambedkar Road, Pune, Maharashtra, India.

出版信息

Am J Trop Med Hyg. 2005 Sep;73(3):566-70.

PMID:16172482

Abstract

An outbreak of encephalitis with a case fatality rate of 78.3% was investigated among children in Gujarat State, India. Twenty-six cases were reported. Three patients had IgM antibodies to Chandipura virus. Virus was isolated from one patient with rhabdomyosarcoma in porcine stable cell lines and in suckling mice. Chandipura virus RNA was present in 9 of 20 acute-phase serum samples, and virus sequences from the present outbreak were closely related to prototype strain (1965) and Andhra Pradesh, India (2003) isolates. Serologic and molecular assays documented the absence of Japanese encephalitis virus, West Nile virus, dengue virus, and paramyxoviruses in clinical samples. The etiologic agent was Chandipura virus, which has become an important encephalitis-causing virus in India.

摘要

在印度古吉拉特邦的儿童中调查了一起病死率为78.3%的脑炎疫情。报告了26例病例。3例患者有针对钱迪普拉病毒的IgM抗体。病毒从1例患有横纹肌肉瘤的患者中分离出来，可在猪稳定细胞系和乳鼠中生长。20份急性期血清样本中有9份存在钱迪普拉病毒RNA，此次疫情的病毒序列与原型毒株（1965年）以及印度安得拉邦（2003年）分离株密切相关。血清学和分子检测证明临床样本中不存在日本脑炎病毒、西尼罗河病毒、登革病毒和副粘病毒。病原体是钱迪普拉病毒，它已成为印度一种重要的致脑炎病毒。