Tandale Babasaheb V, Tikute Sanjaykumar S, Arankalle Vidya A, Sathe Padmakar S, Joshi Manohar V, Ranadive Satish N, Kanojia Phoolchand C, Eshwarachary D, Kumarswamy M, Mishra Akhilesh C
National Institute of Virology, Pune, India.
J Med Virol. 2008 Jan;80(1):118-24. doi: 10.1002/jmv.21041.
A hospital-based surveillance was undertaken between May 2005 and April 2006 to elucidate the contribution of Chandipura virus (CHPV) to acute viral encephalitis cases in children, seroconversion in recovered cases and to compare the seroprevalences of anti-CHPV IgM and N antibodies in areas reporting cases with those without any case of acute viral encephalitis. During this period, 90 cases of acute encephalitis were hospitalized in the pediatric wards of Mahatma Gandhi Memorial (MGM) Hospital, Warangal. There were 49 deaths (Case Fatality Rate, i.e., CFR of 54.4%). Clinical samples and records were obtained from 52 suspected cases. The cases were below 15 years, majority in 0-4 years (35/52, 67.3%). Computerized tomography (CT) scans and cerebro-spinal fluid (CSF) picture favored viral etiology. No neurological sequelae were observed. CHPV etiology was detected in 25 cases (48.1%, n = 52; RNA in 20, IgM in 3 and N antibody seroconversion in 2). JEV etiology was detected in 5 cases (IgM in 4 cases and seroconversion in 1 case). Anti-CHPV IgM seroprevalence in contacts (26/167, 15.6%) was significantly higher (P < 0.05) than in non-contacts (11/430, 2.6%); which was also observed in children <15 years (19/90, 21.1% vs. 3/109, 2.7%). Anti-CHPV N antibody seroprevalence in <15 years contacts (66/90, 73.3%) and non-contacts (77/109, 70.6%) was significantly lower (P < 0.05) than in contacts (75/77, 97.4%) and non-contacts (302/321, 94.1%) more than 15 years respectively. CHPV appears to be the major cause of acute viral encephalitis in children in endemic areas during early monsoon months.
2005年5月至2006年4月期间，开展了一项基于医院的监测，以阐明钱迪普拉病毒（CHPV）对儿童急性病毒性脑炎病例的影响、康复病例中的血清转化情况，并比较报告有病例地区和未报告任何急性病毒性脑炎病例地区抗CHPV IgM和N抗体的血清阳性率。在此期间，90例急性脑炎病例在瓦朗加尔市圣雄甘地纪念（MGM）医院儿科病房住院治疗。其中49例死亡（病死率，即CFR为54.4%）。从52例疑似病例中获取了临床样本和记录。这些病例年龄均在15岁以下，多数为0至4岁（35/52，67.3%）。计算机断层扫描（CT）和脑脊液（CSF）检查结果支持病毒病因。未观察到神经后遗症。在25例病例中检测到CHPV病因（48.1%，n = 52；20例检测到RNA，3例检测到IgM，2例检测到N抗体血清转化）。在5例病例中检测到日本脑炎病毒（JEV）病因（4例检测到IgM，1例检测到血清转化）。接触者中抗CHPV IgM血清阳性率（26/167，15.6%）显著高于非接触者（11/430，2.6%）（P < 0.05）；15岁以下儿童中也观察到这种情况（19/90，21.1%对3/109，2.7%）。15岁以下接触者（66/90，73.3%）和非接触者（77/109，70.6%）中抗CHPV N抗体血清阳性率分别显著低于15岁以上接触者（75/77，97.4%）和非接触者（302/321，94.1%）（P < 0.05）。在季风季节早期，CHPV似乎是流行地区儿童急性病毒性脑炎的主要病因。
