Kratzer Wolfgang, Schmidt Stefan A, Mittrach Christoph, Haenle Mark M, Mason Richard A, Von Tirpitz Christian, Pauls Sandra
Abteilung Innere Medizin I, Universität Ulm, Robert-Koch-Str. 8, DE-89081 Ulm, Germany.
Scand J Gastroenterol. 2005 Aug;40(8):985-91. doi: 10.1080/00365520510015818.
To assess the possibility of quantitative determination of bowel wall vascularity using contrast-enhanced (SonoVue) wideband harmonic imaging ultrasound and the HDI-Lab software in patients with Crohn's disease.
Twenty-one patients (13 F, 8 M, average age 33.8+/-12.7 years, range 21-60 years) with histologically confirmed Crohn's disease and bowel wall thickness > or -5 mm were recruited for the study. All ultrasound examinations were performed using a Philips HDI 5000 scanner. Bowel wall vascularity was determined at the site of maximum bowel wall thickness at baseline and at 30, 60, 90 and 120 s following application of the contrast enhancer SonoVue (1.2 ml) using the HDI-Lab software.
The mean length of bowel segments exhibiting increased wall thickness was 122.3 mm (range: 23-350+/-74.7 mm), with a mean wall thickness of 7.6+/-1.2 mm. Onset of echo enhancement secondary to contrast medium application was observed after an average 13.4 s (range 7-19+/-4.2 s). Echo intensity corresponding to maximum vascularity was measured 30 s after application of contrast medium. Maximum average contrast medium uptake was 217.5% (range 118-466+/-100.1%).
It is possible to quantify bowel wall vascularity accurately in patients with Crohn's disease using contrast-enhanced pulse inversion ultrasound (low-MI).
评估使用超声造影剂（声诺维）的宽带谐波成像超声及HDI-Lab软件对克罗恩病患者肠壁血管进行定量测定的可能性。
招募21例经组织学确诊为克罗恩病且肠壁厚度≥5mm的患者（13例女性，8例男性，平均年龄33.8±12.7岁，范围21 - 60岁）进行本研究。所有超声检查均使用飞利浦HDI 5000扫描仪。在基线时以及注射超声造影剂声诺维（1.2ml）后30、60、90和120秒，使用HDI-Lab软件在肠壁厚度最大处测定肠壁血管情况。
肠壁厚度增加的肠段平均长度为122.3mm（范围：23 - 350±74.7mm），平均肠壁厚度为7.6±1.2mm。注射造影剂后平均13.4秒（范围7 - 19±4.2秒）观察到造影剂增强回声开始出现。在注射造影剂30秒后测量对应最大血管的回声强度。最大平均造影剂摄取率为217.5%（范围118 - 466±100.1%）。
使用超声造影剂增强的脉冲反转超声（低机械指数）能够准确量化克罗恩病患者的肠壁血管情况。
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