Falconi Mariano, Oberti Pablo, Krauss Juan, Domenech Alberto, Cesáreo Vicente, Bracco Daniel, Pizarro Rodolfo
Division of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Echocardiography. 2005 Sep;22(8):629-35. doi: 10.1111/j.1540-8175.2005.04012.x.
The objective of this study is to test the hypothesis that the absence of flow communication in aortic intramural hematoma (IMH) involving the descending aorta may have a different clinical course compared with aortic dissection (AD).
We prospectively evaluated clinical and echocardiographic data in AD (76 patients) and IMH (27 patients) of the descending thoracic aorta.
Patients did not differ with regard to age, gender, or clinical presentation. IMH and AD had the same predictors of complications at follow-up: aortic diameter (>5 cm) at diagnosis and persistent back pain. Surgical treatment was more frequently selected in AD (39% vs. 22%, P < 0.01) and AD patients who underwent surgical treatment had higher mortality than those with IMH (36% vs. 17%, P < 0.01). There was no difference in mortality with medical treatment (14% in AD vs. 19% in IMH, P = 0.7). During follow-up, of 23 patients with IMH, 11 (47%) showed complete resolution or regression, 6 (26%) increased the diameter of the descending aorta, and typical AD developed in 3 patients (13%). No changes occurred in 14% of the group. Three-year survival rate did not show significant differences between both groups (82 +/- 6% in IMH vs. 75 +/- 7% in AD, P = 0.37).
IMH of the descending thoracic aorta has a relatively frequent rate of complications at follow-up, including dissection and aneurysm formation. Medical treatment with very frequent imaging and timed elective surgery in cases with complications allows a better patient management.
本研究的目的是检验以下假设:累及降主动脉的主动脉壁内血肿(IMH)不存在血流交通,其临床病程可能与主动脉夹层(AD)不同。
我们前瞻性评估了降主动脉AD(76例患者)和IMH(27例患者)的临床和超声心动图数据。
患者在年龄、性别或临床表现方面无差异。IMH和AD在随访时并发症的预测因素相同:诊断时主动脉直径(>5 cm)和持续性背痛。AD患者更常选择手术治疗(39%对22%,P<0.01),接受手术治疗的AD患者死亡率高于IMH患者(36%对17%,P<0.01)。药物治疗的死亡率无差异(AD为14%,IMH为19%,P = 0.7)。随访期间,23例IMH患者中,11例(47%)完全消退或缩小,6例(26%)降主动脉直径增大,3例(13%)发展为典型AD。该组14%无变化。两组三年生存率无显著差异(IMH为82±6%,AD为75±7%,P = 0.37)。
降主动脉IMH在随访时并发症发生率相对较高,包括夹层形成和动脉瘤形成。对于并发症患者,采用频繁成像的药物治疗和适时的择期手术可实现更好的患者管理。