Pridmore Saxby, Oberoi Gajinder, Marcolin Marco, George Mark
Division of Psychiatry, University of Tasmania, Hobart, Tas., Australia.
Australas Psychiatry. 2005 Sep;13(3):258-65. doi: 10.1080/j.1440-1665.2005.02197.x.
To examine evidence suggesting a potential role for transcranial magnetic stimulation (TMS) in the treatment of chronic pain.
Chronic pain is characterized by brain changes that can reasonably be presumed to be associated with hyperalgesia, as occurs with neuropathic changes in the periphery. TMS has the ability to induce plastic changes in the cortex at the site of stimulation and at connected sites, including the spinal cord. It also has the ability to influence the experience of experimental/acute pain. In studies of TMS in chronic pain, there is some evidence that temporary relief can be achieved in a proportion of sufferers. Chronic pain is common. Current treatments are often ineffective and complicated by side-effects. Work to this point is encouraging, but systematic assessment of stimulation parameters is necessary if TMS is to achieve a role in the treatment of chronic pain. Maintenance TMS is currently provided in relapsing major depression and may be a useful model in chronic pain management.
研究表明经颅磁刺激（TMS）在慢性疼痛治疗中可能发挥作用的证据。
慢性疼痛的特征是脑部发生变化，合理推测这些变化与痛觉过敏有关，就像外周神经病变时发生的情况一样。TMS能够在刺激部位及包括脊髓在内的相连部位诱导皮质发生可塑性变化。它还能够影响实验性/急性疼痛的体验。在TMS治疗慢性疼痛的研究中，有一些证据表明部分患者可获得暂时缓解。慢性疼痛很常见。目前的治疗方法往往无效且伴有副作用。到目前为止的研究工作令人鼓舞，但如果TMS要在慢性疼痛治疗中发挥作用，就必须对刺激参数进行系统评估。维持性TMS目前用于复发性重度抑郁症的治疗，可能是慢性疼痛管理中的一个有用模式。
