Avery David H, Holtzheimer Paul E, Fawaz Walid, Russo Joan, Neumaier John, Dunner David L, Haynor David R, Claypoole Keith H, Wajdik Chandra, Roy-Byrne Peter
Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, Seattle, Washington 98104-2499, USA.
J Nerv Ment Dis. 2007 May;195(5):378-81. doi: 10.1097/NMD.0b013e31802f58d1.
This study evaluated the change in reported pain in patients with medication-resistant major depression receiving transcranial magnetic stimulation (TMS) compared with sham stimulation. In this study, 68 subjects with major depression were randomized to either TMS or sham stimulation. Repetitive TMS was delivered to the left dorsolateral prefrontal cortex at a frequency of 10 Hz in 5-second trains at 110% of the estimated prefrontal cortex threshold. The level of pain was assessed before, during, and after treatment using the Systematic Assessment for Treatment Emergent Effects (SAFTEE) item for pain in the muscles, bones, and joints. Compared with sham, TMS was associated with a significant (p < 0.05) reduction in the SAFTEE pain item during the study. The reduction in pain could not be explained by the antidepressant effects.
本研究评估了药物难治性重度抑郁症患者接受经颅磁刺激（TMS）与假刺激相比，报告的疼痛变化。在本研究中，68名重度抑郁症患者被随机分为TMS组或假刺激组。重复经颅磁刺激以10赫兹的频率，以5秒的脉冲串，在估计的前额叶皮质阈值的110%下，施加于左侧背外侧前额叶皮质。使用治疗突发效应系统评估（SAFTEE）中关于肌肉、骨骼和关节疼痛的项目，在治疗前、治疗期间和治疗后评估疼痛程度。与假刺激相比，在研究期间，TMS与SAFTEE疼痛项目的显著（p < 0.05）降低相关。疼痛的减轻无法用抗抑郁作用来解释。
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