Davidovich E, Schwarz Z, Davidovitch M, Eidelman E, Bimstein E
Department of Pediatric Dentistry, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
J Clin Periodontol. 2005 Oct;32(10):1076-82. doi: 10.1111/j.1600-051X.2005.00812.x.
Describe the oral condition of chronic renal failure and healthy subjects, and the relationship between oral variables, chronic renal failure (CRF) conditions, and their treatment.
Four renal failure groups: chronic renal disease (n=22); undergoing dialysis (n=22); after dialysis and transplant (n=21); and after transplant (n=32), and a healthy control (n=38) were examined. Caries, enamel hypoplasia, pulp obliteration, plaque index, gingival bleeding, recession, overgrowth and index, probing depths, attachment loss, renal treatments and their relations with the oral variables were analysed.
The renal failure groups had higher gingival index (GI) and bleeding, probing depths, attachment loss, hypoplasia and obliteration and less caries, than the control. Plaque was higher in the dialysis and pre-dialysis (PD) groups. Overgrowth was evident after transplant. The PD group showed lower GI than other renal groups. Dialysis duration and end-stage renal failure significantly correlated with gingivitis, probing depth, attachment loss and enamel hypoplasia. Immuran correlated positively with probing depth, gingival recession and attachment loss. Normiten and Nifedipine had positive correlations with gingival overgrowth.
CRF patients are characterized by pulp obliteration, gingival and periodontal diseases. Duration of end stage renal failure and type of systemic treatment have a significant influence on the oral condition.
描述慢性肾衰竭患者和健康受试者的口腔状况，以及口腔变量、慢性肾衰竭（CRF）病情及其治疗之间的关系。
对四组肾衰竭患者和一组健康对照进行检查。四组肾衰竭患者分别为：慢性肾病患者（n = 22）；正在接受透析的患者（n = 22）；透析及移植术后患者（n = 21）；移植术后患者（n = 32）；健康对照组（n = 38）。分析了龋齿、釉质发育不全、牙髓闭锁、菌斑指数、牙龈出血、牙龈退缩、牙龈增生及指数、探诊深度、附着丧失、肾脏治疗情况及其与口腔变量的关系。
与对照组相比，肾衰竭组的牙龈指数（GI）、牙龈出血、探诊深度、附着丧失、发育不全及闭锁情况更为严重，而龋齿情况则较轻。透析组和透析前组的菌斑指数较高。移植术后牙龈增生明显。透析前组的GI低于其他肾衰竭组。透析时间和终末期肾衰竭与牙龈炎、探诊深度、附着丧失和釉质发育不全显著相关。硫唑嘌呤与探诊深度、牙龈退缩和附着丧失呈正相关。硝苯地平控释片和硝苯地平与牙龈增生呈正相关。
CRF患者的特征为牙髓闭锁、牙龈及牙周疾病。终末期肾衰竭的病程和全身治疗类型对口腔状况有显著影响。
