Velázquez Claudia, Calzada Fernando, Torres Javier, González Felipe, Ceballos Guillermo
Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 degrees Piso, Centro Médico Nacional Siglo XXI, IMSS, Col. Doctores, CP 06725, México DF.
J Ethnopharmacol. 2006 Jan 3;103(1):66-70. doi: 10.1016/j.jep.2005.06.046. Epub 2005 Sep 19.
Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.
对墨西哥用于治疗胃肠道疾病的26种药用植物的水提取物和甲醇提取物进行了筛选，以评估它们在大鼠空肠袢模型中对霍乱毒素诱导的肠道分泌的抗分泌活性。提取物的测试剂量为300 mg/kg。在测试的56个样品中，五指悬铃花、长叶希藤和罗勒的两种提取物活性最强，抑制值在68.0%至87.6%之间。另一方面，墨西哥老鹳草（地上部分）的甲醇提取物和博落回的水提取物活性最高，抑制值分别为93.4%和86.0%。本研究所得结果为墨西哥药用植物用于治疗腹泻等胃肠道疾病提供了一些科学依据。
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