Degu Amsalu, Kefale Belayneh, Alemayehu Diriba, Tegegne Gobezie Temesgen
School of Pharmacy and Health Sciences, United States International University-Africa, Nairobi, Kenya.
Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Evid Based Complement Alternat Med. 2020 Apr 13;2020:8318713. doi: 10.1155/2020/8318713. eCollection 2020.
The herbal medicine practitioners in Ethiopia have used a wide range of medicinal plants as antidiarrheal agents. Among these, and were claimed to have antidiarrheal activity in Ethiopian folklore medicine. Hence, the aim of the present study was to evaluate the antidiarrheal activity of the crude extracts of and in mice.
The crude extracts were obtained by cold maceration with 80% methanol, and its antidiarrheal activities were evaluated using a castor oil-induced diarrheal model. The test groups were treated with 100, 200, and 400 mg/kg body weight (bw) of the crude extract of each plant, while the positive controls and negative controls were given loperamide (3 mg/kg.bw) and 2% Tween 80 (10 ml/kg.bw), respectively.
In the castor oil-induced model, the crude extract of (200 and 400 mg/kg.bw) significantly prolonged the onset of diarrhea in mice. Besides, it also showed a significant reduction in the frequency of stooling and weight of feces. Contrastingly, the crude extract of had a significant effect in delaying the onset of time of diarrhea and reduction of the frequency of stool and the weight of feces only at the maximum tested dose (400 mg/kg.bw).
The present study demonstrated that the crude leaves extract of (200 and 400 mg/kg.bw) and (400 mg/kg.bw) possessed significant antidiarrheal activity in the castor oil-induced diarrheal model.
埃塞俄比亚的草药从业者使用多种药用植物作为抗腹泻剂。其中，[植物名称1]和[植物名称2]在埃塞俄比亚民间医学中据称具有抗腹泻活性。因此，本研究的目的是评估[植物名称1]和[植物名称2]粗提物在小鼠中的抗腹泻活性。
通过用80%甲醇冷浸获得粗提物，并使用蓖麻油诱导的腹泻模型评估其抗腹泻活性。试验组分别用每种植物粗提物的100、200和400毫克/千克体重（bw）进行处理，而阳性对照组和阴性对照组分别给予洛哌丁胺（3毫克/千克体重）和2%吐温80（10毫升/千克体重）。
在蓖麻油诱导的模型中，[植物名称1]的粗提物（200和400毫克/千克体重）显著延长了小鼠腹泻的发作时间。此外，它还使排便频率和粪便重量显著降低。相比之下，[植物名称2]的粗提物仅在最大测试剂量（400毫克/千克体重）时对延迟腹泻发作时间、降低排便频率和粪便重量有显著作用。
本研究表明，[植物名称1]（200和400毫克/千克体重）和[植物名称2]（400毫克/千克体重）的粗叶提取物在蓖麻油诱导的腹泻模型中具有显著的抗腹泻活性。
