Yu Lin-zhong, Wu Jie-yong, Luo Jia-bo, Chen Yu-rao, Lin Hui
Department of Traditional Chinese Medicine Pharmacology, Faculty of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Sep;25(9):1132-4.
To investigate the relations between different compositions of Gegenqinlian decoction and their effects on experimental shigellosis in rabbits to explore the composition protocol of Gegenqinlian decoction.
Rabbit models of intestinal invasion induced by Shigella flexneri was established by directly inoculating the bacterium in the colon after cecum bypass operation. The effects of different compositions of Gegenqinlian decoction on the indexes of colitis and the bacterial count of Shigella in the colon content and colon tissue were investigated by orthogonal design.
According to the bacterial count of Shigella in the colon, Coptis chinensis franch and Scutellaria baicalensis Georgi are the main effective drugs, but they antagonized each other, so that the best combination protocol was Coptis chinensis Franch only.
Among the components of Gegenqinlian decoction, Coptis chinensis franch has the strongest pharmacological effect against bacteria and Glycyrrhina wralensis fisch is the most effective to ameliorate pathological lesions.
探讨葛根芩连汤不同配伍与其对家兔实验性志贺菌病疗效的关系，以探寻葛根芩连汤的组方规律。
采用盲肠旁路术后直接向结肠接种福氏志贺菌的方法，建立家兔肠道侵袭模型。运用正交设计法，观察葛根芩连汤不同配伍对结肠炎指标及结肠内容物和结肠组织中志贺菌菌数的影响。
以结肠中志贺菌菌数为指标，黄连和黄芩是主要有效药物，但二者存在拮抗作用，最佳组方为单用黄连。
在葛根芩连汤各组成中，黄连抗细菌药理作用最强，甘草改善病理损伤作用最显著。
