Rabbani G H, Albert M J, Hamidur Rahman A S, Moyenul Isalm M, Nasirul Islam K M, Alam K
Physiology Research Centre, International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka 1000, Bangladesh. rabbani@icddrb. org
J Infect Dis. 1999 Feb;179(2):390-7. doi: 10.1086/314584.
Because of the metabolic and antibacterial actions of short-chain fatty acids (SCFA), their roles in modifying the clinicopathologic features of shigellosis were evaluated in a rabbit model of shigellosis. Acute colitis was induced in adult rabbits by intracolonic administration of Shigella flexneri 2a. After 24 h, rabbits were given 6-h colonic infusions of SCFA (acetate, propionate, n-butyrate; 60:30:40 mM) or SCFA-free solution (control); groups of rabbits were killed in batches of 2 or 3 animals at 24, 48, 72, and 96 h after treatment, for histologic and bacteriologic assessment. SCFA significantly reduced fecal blood and mucus and improved clinical symptoms. Histologically, SCFA significantly (P<.01) reduced mucosal congestion, cellular infiltration, and necrotic changes. SCFA also significantly (P<.05) reduced the number of shigellae in the colon. No such improvements occurred in the control group. SCFA may be useful agents in improving clinicopathologic features of shigellosis and should be clinically evaluated.
由于短链脂肪酸（SCFA）的代谢和抗菌作用，在志贺氏菌病兔模型中评估了它们对志贺氏菌病临床病理特征的影响。通过结肠内给予弗氏志贺氏菌2a诱导成年兔发生急性结肠炎。24小时后，给兔子进行6小时的结肠内SCFA（乙酸盐、丙酸盐、正丁酸盐；60:30:40 mM）或无SCFA溶液（对照）灌注；在治疗后24、48、72和96小时，将兔子按每组2或3只分批处死，进行组织学和细菌学评估。SCFA显著减少了粪便中的血液和黏液，并改善了临床症状。组织学上，SCFA显著（P<0.01）减轻了黏膜充血、细胞浸润和坏死变化。SCFA还显著（P<0.05）减少了结肠中志贺氏菌的数量。对照组未出现此类改善。SCFA可能是改善志贺氏菌病临床病理特征的有用药物，应进行临床评估。
