Xu Chun-sheng, Li Zhi-liang, Zhang Hua, Yan Quan-neng, Wu Hong-chao, Tang Chao-shu
Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Sep;25(9):1149-51.
To observe the dynamic changes of plasma adrenomedullin (ADM) levels and the effect of enalapril intervention in diabetic rats.
Fifty-two wistar rats were grouped into 1- and 3-month groups (7 each), both including a control and a streptozotocin-induced diabetic group. The 5-month group was divided into control, diabetic and enalapril-treatment diabetic groups (8 each, the last group receiving oral enalapril treatment at the daily dose of 2 mg/kg from the first to the fifth month after diabetes induction). Blood samples were collected from the heart of the rats at the end of 1, 3 and 5 months for determination of plasma ADM concentrations radioimmunoassay.
Plasma ADM levels were significantly higher in diabetic rats than in the corresponding control rats in 1- and 3-month groups. ADM levels in the diabetic rats of 5-month group were significantly decreased in comparison with that of 1- and 3-month groups. In 5-month group, plasma ADM levels of enalapril-treated diabetic rats elevated significantly in comparison with that in the control rats and the diabetic rats without enalapril treatment.
ADM may play an important role in the pathophysiology of diabetes.
观察糖尿病大鼠血浆肾上腺髓质素（ADM）水平的动态变化及依那普利干预的效果。
将52只Wistar大鼠分为1个月组和3个月组（每组7只），每组均包括对照组和链脲佐菌素诱导的糖尿病组。5个月组分为对照组、糖尿病组和依那普利治疗糖尿病组（每组8只，最后一组在糖尿病诱导后第1至5个月每天口服2mg/kg依那普利）。在1、3和5个月结束时从大鼠心脏采集血样，用放射免疫分析法测定血浆ADM浓度。
1个月组和3个月组中，糖尿病大鼠的血浆ADM水平显著高于相应的对照组大鼠。5个月组糖尿病大鼠的ADM水平与1个月组和3个月组相比显著降低。在5个月组中，依那普利治疗的糖尿病大鼠的血浆ADM水平与对照组大鼠和未接受依那普利治疗的糖尿病大鼠相比显著升高。
ADM可能在糖尿病的病理生理学中起重要作用。
