Department of Clinical Pharmacology, University of Medical Sciences, Poznan, Poland.
Med Sci Monit. 2009 Nov;15(11):BR334-8.
Hyperglycemia enhances cataractogenesis. Elevated glucose level is commonly accompanied by arterial hypertension, for which angiotensin-converting enzyme (ACE) inhibitors (ACEIs) are a widely used intervention. ACE inhibitors exert some endothelial pleiotropic actions and can beneficially modulate glucose control and some other metabolic pathways. The purpose of this study was to evaluate the effect of ACEIs on cataract formation in experimental alloxan-induced diabetes in rabbits and assess the role of the reactive function group of the ACEIs in this process.
MATERIAL/METHODS: Two study and two control groups of rabbits were examined. In the study groups and in one of the control groups, diabetes was induced by alloxan. The study groups were assigned to receive captopril or enalapril for six months; the controls received distilled water. Glucose concentration was monitored with a glucometer. A biomicroscope and an ophthalmoscope were used to evaluate lens opacity and cataractogenesis.
Six-month administration of ACEI to rabbis resulted in a delay of diabetic cataractogenesis. The rate of cataract formation was significantly lower in the group treated with captopril than in the enalapril group. A difference in morphology of lens opacity formation between the two study groups was observed.
ACEIs delay diabetic cataractogenesis in an experimental animal model. The ACEI functional groups have different influences on the pattern and rate of lens opacity.
高血糖会增强白内障的形成。高血糖水平通常伴随着动脉高血压，血管紧张素转换酶（ACE）抑制剂（ACEIs）是一种广泛使用的干预方法。ACEIs 发挥了一些内皮细胞的多效作用，并可以有益地调节葡萄糖控制和其他一些代谢途径。本研究的目的是评估 ACEIs 对实验性兔链脲佐菌素诱导糖尿病性白内障形成的影响，并评估 ACEIs 的反应性功能基团在这一过程中的作用。
材料/方法：检查了两组研究组和两组对照组的兔子。在研究组和对照组之一中，通过链脲佐菌素诱导糖尿病。研究组接受卡托普利或依那普利治疗六个月；对照组接受蒸馏水。使用血糖仪监测血糖浓度。使用生物显微镜和检眼镜评估晶状体混浊和白内障的形成。
ACEI 对兔子的六个月给药导致糖尿病性白内障形成的延迟。与依那普利组相比，用卡托普利治疗的组白内障形成的速度明显较低。在两组研究组之间观察到晶状体混浊形成的形态学差异。
ACEIs 可延缓实验动物模型中的糖尿病性白内障形成。ACEI 功能基团对晶状体混浊的模式和速度有不同的影响。
