Kopp Hans-Georg, Avecilla Scott T, Hooper Andrea T, Rafii Shahin
Weill Medical College of Cornell University, New York, New York, USA.
Physiology (Bethesda). 2005 Oct;20:349-56. doi: 10.1152/physiol.00025.2005.
The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.
骨髓血管龛由薄壁且有窗孔的窦状血管网络组成，其完整性由周围的造血细胞维持和支持。然而，这种依赖性是高度相互的，因为骨髓脉管系统不仅为成熟造血细胞进入外周循环提供了通道，而且还是造血祖细胞，尤其是巨核细胞分化的场所，并为造血的完全重建奠定了基础。
