Colmone Angela, Sipkins Dorothy A
Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Ill 60637, USA.
Transl Res. 2008 Jan;151(1):1-9. doi: 10.1016/j.trsl.2007.09.003. Epub 2007 Oct 4.
Specific tissue microenvironments, or niches, are critical for homing and maintenance of both stem cells and tumor cells in vivo. Little is known, however, about the molecular interactions between individual cells within these microenvironments. Recent studies that describe a newly identified hematopoietic stem and tumor cell vascular niche in the bone marrow (BM) suggest a critical role for vascular endothelial cell signaling and raise the possibility that bidirectional interactions of these cells with the vasculature regulate the niche dynamically. The mechanisms that govern hematopoietic stem cell (HSC)/tumor cell cross-talk with endothelial cells provide a promising new direction for future studies. Here we review recent advances that open new avenues of study in this field.
特定的组织微环境，即生态位，对于体内干细胞和肿瘤细胞的归巢及维持至关重要。然而，对于这些微环境中单个细胞之间的分子相互作用却知之甚少。最近的研究描述了骨髓（BM）中一个新发现的造血干细胞和肿瘤细胞血管生态位，提示血管内皮细胞信号传导起关键作用，并提出这些细胞与脉管系统的双向相互作用可能动态调节该生态位。造血干细胞（HSC）/肿瘤细胞与内皮细胞相互作用的机制为未来研究提供了一个有前景的新方向。在此，我们综述了开启该领域新研究途径的近期进展。
