Hecht M J, Fellner C, Schmid A, Neundörfer B, Fellner F A
Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany.
Neuroradiology. 2005 Nov;47(11):805-8. doi: 10.1007/s00234-005-1421-5. Epub 2005 Sep 21.
Signal shortening of the motor cortex in T2-weighted MR images is a frequent finding in patients with amyotrophic lateral sclerosis (ALS). The cause of signal shortening in ALS is unknown, although iron deposits have been suggested. To test this hypothesis, we acquired T2*-weighted gradient-echo (GRE) MR images in addition to T2-weighted turbo spin-echo in 69 patients with ALS. Signal shortening in T2-weighted images was found in 31 patients. In T2*-weighted GRE images, only three patients had signal shortening. One patient with additional bifrontal haemorrhage had frontal but no motor cortex signal shortening. Iron deposits do not cause cortical signal shortening in patients with ALS predominantly. Other factors are presumably more important in the generation of cortical T2 shortening in ALS.
在肌萎缩侧索硬化症（ALS）患者的T2加权磁共振成像（MR图像）中，运动皮层信号缩短是常见表现。尽管有人提出是铁沉积导致的，但ALS中信号缩短的原因尚不清楚。为验证这一假设，我们对69例ALS患者除进行T2加权快速自旋回波成像外，还采集了T2加权梯度回波（GRE）MR图像。在31例患者的T2加权图像中发现信号缩短。在T2加权GRE图像中，只有3例患者出现信号缩短。1例伴有双侧额叶出血的患者额叶有信号缩短，但运动皮层无信号缩短。铁沉积并非ALS患者皮层信号缩短的主要原因。其他因素可能在ALS患者皮层T2缩短的产生中更为重要。
