Chen J C, Hardy P A, Kucharczyk W, Clauberg M, Joshi J G, Vourlas A, Dhar M, Henkelman R M
Department of Radiology, University of Toronto, Ontario, Canada.
AJNR Am J Neuroradiol. 1993 Mar-Apr;14(2):275-81.
To test the hypothesis that the T2 shortening observed on MR images of the brain in patients with Parkinson and Huntington diseases is due to tissue iron deposition.
Tissue iron and ferritin assays were performed on postmortem putamen and globus pallidus samples from subjects with Huntington and Parkinson disease. The assays were correlated with T2 measurements. Normal samples were included as controls.
There were significant differences in T2 values, and iron and ferritin concentrations among the putamen samples. Compared with normal controls, subjects with Huntington disease had approximately a threefold increase in iron and a sixfold increase in ferritin concentrations; however, they also had the longest T2 values. Parkinson disease putamens had milder elevations of iron concentrations above that of controls (33%) and demonstrated slightly shorter T2 values. The globus pallidus samples demonstrated a similar trend in their T2s, iron, and ferritin levels, but there was a larger overlap in the T2 values.
Our results indicate that tissue iron and ferritin concentrations are elevated in the brains of subjects with both Parkinson and Huntington disease but the elevated concentrations do not correlate with T2 shortening. Although iron and ferritin can shorten T2, we conclude that other factors must play a significant role in determining the T2 relaxation time and that iron or ferritin are not dominant in this regard.
验证帕金森病和亨廷顿病患者脑部磁共振成像（MRI）上观察到的T2缩短是由于组织铁沉积这一假说。
对亨廷顿病和帕金森病患者死后的壳核和苍白球样本进行组织铁和铁蛋白检测。检测结果与T2测量值相关。纳入正常样本作为对照。
壳核样本的T2值、铁和铁蛋白浓度存在显著差异。与正常对照相比，亨廷顿病患者的铁浓度约增加三倍，铁蛋白浓度增加六倍；然而，他们的T2值也是最长的。帕金森病患者的壳核铁浓度比对照组轻度升高（33%），T2值略短。苍白球样本在T2值、铁和铁蛋白水平上呈现类似趋势，但T2值的重叠更大。
我们的结果表明，帕金森病和亨廷顿病患者大脑中的组织铁和铁蛋白浓度升高，但升高的浓度与T2缩短无关。虽然铁和铁蛋白可以缩短T2，但我们得出结论，其他因素在决定T2弛豫时间方面必须发挥重要作用，而铁或铁蛋白在这方面并非主要因素。
