Athanasou N A, Quinn J M
Department of Pathology, Nuffield Orthopaedic Centre, Oxford, England.
Cancer. 1992 Jul 15;70(2):469-75. doi: 10.1002/1097-0142(19920715)70:2<469::aid-cncr2820700215>3.0.co;2-0.
The nature of keratin-associated giant cells of a pilar tumor of scalp (PTS) was assessed for several osteoclast-like characteristics, including antigenic phenotype, ultrastructure, calcitonin response, and bone resorbing ability. The giant cells, unlike osteoclasts, did not respond morphologically to calcitonin, had the antigenic phenotype of cells of the monocyte/macrophage lineage, and showed ultrastructural features of macrophage polykaryons. However, like osteoclasts, the giant cells were capable of bone resorption, including resorption pit formation. This indicates that the giant cells in PTS are of histiocytic and not osteoclastic differentiation. Bone resorption by tumor-associated macrophage polykaryons shows that this is not a unique defining characteristic of osteoclasts. It also suggests that such histiocytic cells may contribute to the osteolysis associated with skeletal metastases of squamous and other carcinomas.
对头皮毛源性肿瘤（PTS）中角蛋白相关巨细胞的性质进行了评估，以确定其几种破骨细胞样特征，包括抗原表型、超微结构、降钙素反应和骨吸收能力。与破骨细胞不同，这些巨细胞在形态上对降钙素无反应，具有单核细胞/巨噬细胞谱系细胞的抗原表型，并表现出巨噬细胞多核体的超微结构特征。然而，与破骨细胞一样，这些巨细胞能够进行骨吸收，包括形成吸收陷窝。这表明PTS中的巨细胞是组织细胞分化而非破骨细胞分化。肿瘤相关巨噬细胞多核体的骨吸收表明这不是破骨细胞的独特定义特征。这也表明这种组织细胞可能促成与鳞状细胞癌和其他癌的骨转移相关的骨溶解。
