Athanasou N A, Quinn J, Ferguson D J, McGee J O
Nuffield Department of Pathology, John Radcliffe Hospital, Headington, Oxford, UK.
Br J Cancer. 1991 Apr;63(4):527-33. doi: 10.1038/bjc.1991.125.
The antigenic phenotype, ultrastructure and bone resorbing ability of mononuclear and multinucleated giant cells of four giant cell tumour of tendon sheath (GCTTS) lesions was assessed. Both the giant cells and the mononuclear cells exhibited the antigenic phenotype of cells of the monocyte/macrophage lineage. The giant cells, unlike osteoclasts, did not respond morphologically to calcitonin and showed ultrastructural and immunophenotypic features of macrophage polykaryons. However, like osteoclasts, the giant cells showed direct evidence of resorption pit formation on bone slices. This indicates that the GCTTS is composed of cells of histiocytic differentiation with the giant and mononuclear cell components expressing a similar antigenic phenotype. Bone resorption by macrophage polykaryons shows that this is not a unique defining characteristic of osteoclasts. Qualitative differences in the degree and pattern of bone resorption by macrophage polykaryons distinguish it from that of osteoclasts and may underlie the clinical behaviour of osteolytic lesions.
对4例腱鞘巨细胞瘤（GCTTS）病变的单核和多核巨细胞的抗原表型、超微结构及骨吸收能力进行了评估。巨细胞和单核细胞均表现出单核细胞/巨噬细胞谱系细胞的抗原表型。与破骨细胞不同，巨细胞对降钙素无形态学反应，并表现出巨噬细胞多核体的超微结构和免疫表型特征。然而，与破骨细胞一样，巨细胞在骨切片上有骨吸收陷窝形成的直接证据。这表明GCTTS由组织细胞分化的细胞组成，其中巨细胞和单核细胞成分表达相似的抗原表型。巨噬细胞多核体的骨吸收表明这不是破骨细胞独特的定义特征。巨噬细胞多核体在骨吸收程度和模式上的定性差异将其与破骨细胞区分开来，这可能是溶骨性病变临床行为的基础。
