Epstein J H, Cleaver J E
Department of Dermatology, University of California, San Francisco 94143-0750.
Cancer Res. 1992 Jul 15;52(14):4053-4.
Chronic irradiation (three times a week) with ultraviolet B light of the skin of hairless mouse Uscd (Hr) strains resulted in the induction of skin tumors after 25 to 41 weeks. Topical applications of 3-aminobenzamide (3AB; 0.1 or 1 M) after each irradiation significantly shortened the earliest time of onset of tumors to 13 to 25 weeks and increased the number of animals that developed tumors over 41 weeks from 67% without 3AB to 73% and 81% with 0.1 and 1 M 3AB, respectively. 3-Aminobenzamide has previously been shown to inhibit radiation-induced transformation in vitro. In vivo, 3AB has the opposite effect, indicating the need for caution in extrapolating from in vitro systems to carcinogenesis in vivo.
对无毛小鼠Uscd（Hr）品系的皮肤每周进行三次紫外线B慢性照射，25至41周后诱发了皮肤肿瘤。每次照射后局部应用3 - 氨基苯甲酰胺（3AB；0.1或1 M）可显著缩短肿瘤最早出现的时间至13至25周，并使在41周内发生肿瘤的动物数量增加，从无3AB时的67%分别增至使用0.1 M 3AB时的73%和使用1 M 3AB时的81%。先前已证明3 - 氨基苯甲酰胺在体外可抑制辐射诱导的细胞转化。在体内，3AB具有相反的作用，这表明在从体外系统推断体内致癌作用时需谨慎。
