Castellsagué Xavier, Peeling Rosanna W, Franceschi Silvia, de Sanjosé Silvia, Smith Jennifer S, Albero Ginesa, Díaz Mireia, Herrero Rolando, Muñoz Nubia, Bosch F Xavier
Cancer Epidemiology and Registration Unit, Institut d'Investigació Biomèdica de Bellvitge, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain.
Am J Epidemiol. 2005 Nov 1;162(9):907-16. doi: 10.1093/aje/kwi284. Epub 2005 Sep 21.
Male circumcision has been shown to reduce the risk of acquiring and transmitting a number of venereal infections. However, little is known about the association between male circumcision and the risk of Chlamydia trachomatis infection in the female partner. The authors pooled data on 305 adult couples enrolled as controls in one of five case-control studies of invasive cervical cancer conducted in Thailand, the Philippines, Brazil, Colombia, and Spain between 1985 and 1997. Women provided blood samples for C. trachomatis and Chlamydia pneumoniae antibody detection; a type-specific microfluorescence assay was used. Multivariate odds ratios were computed for the association between male circumcision status and chlamydial seropositivity in women. Compared with women with uncircumcised partners, those with circumcised partners had a 5.6-fold reduced risk of testing seropositive for C. trachomatis (82% reduction; odds ratio = 0.18, 95% confidence interval: 0.05, 0.58). The inverse association was also observed after restricting the analysis to monogamous women and their only male partners (odds ratio = 0.21, 95% confidence interval: 0.06, 0.72). In contrast, seropositivity to C. pneumoniae, a non-sexually-transmitted infection, was not significantly related to circumcision status of the male partner. These findings suggest that male circumcision could reduce the risk of C. trachomatis infection in female sexual partners.
男性包皮环切术已被证明可降低感染和传播多种性传播感染的风险。然而，关于男性包皮环切术与女性性伴侣感染沙眼衣原体风险之间的关联，人们所知甚少。作者汇总了1985年至1997年间在泰国、菲律宾、巴西、哥伦比亚和西班牙进行的五项宫颈癌病例对照研究之一中作为对照纳入的305对成年夫妇的数据。女性提供血液样本用于检测沙眼衣原体和肺炎衣原体抗体；采用了一种型特异性微荧光检测法。计算了男性包皮环切状态与女性衣原体血清阳性之间关联的多变量优势比。与伴侣未行包皮环切术的女性相比，伴侣行包皮环切术的女性沙眼衣原体血清检测呈阳性的风险降低了5.6倍（降低82%；优势比=0.18，95%置信区间：0.05，0.58）。在将分析限制于一夫一妻制女性及其唯一男性伴侣后，也观察到了这种负相关（优势比=0.21，95%置信区间：0.06，0.72）。相比之下，肺炎衣原体（一种非性传播感染）的血清阳性与男性伴侣的包皮环切状态无显著关联。这些发现表明，男性包皮环切术可降低女性性伴侣感染沙眼衣原体的风险。
