Serraino D, Piselli P, Angeletti C l, Scuderi M, Ippolito G, Capobianchi M R
Department of Epidemiology, INMI, L Spallanzani IRCCS, Roma, Italy.
J Biol Regul Homeost Agents. 2005 Jan-Jun;19(1-2):63-70.
The Epstein-Barr virus (EBV) is ubiquitous worldwide, with greater than 80% of people over the age of 30 having been infected. Once EBV infection has occurred, it remains for the lifetime of the individual, making EBV one of the most persistant viruses that infect humans. EBV is strongly associated with the development of several cancers, in particular with Burkitt's lymphoma, Hodgkin's disease, and lymphoproliferative disorders which complicate immune suppression conditions. These EBV-associated neoplasms are characterized by peculiar geographic distributions and distinctive epidemiologic features. In this review, the main epidemiological aspects of the relationship between EBV infection and cancer are outlined, and recent advances in the mechanisms underlying EBV-induced growth transformation are summarized.
爱泼斯坦-巴尔病毒（EBV）在全球范围内普遍存在，30岁以上人群中超过80%曾感染过该病毒。一旦发生EBV感染，它会在个体的一生中持续存在，这使得EBV成为感染人类的最持久的病毒之一。EBV与多种癌症的发生密切相关，特别是与伯基特淋巴瘤、霍奇金病以及使免疫抑制状况复杂化的淋巴增殖性疾病有关。这些与EBV相关的肿瘤具有独特的地理分布和鲜明的流行病学特征。在本综述中，概述了EBV感染与癌症关系的主要流行病学方面，并总结了EBV诱导生长转化潜在机制的最新进展。
