Kopera D, Kokol R, Berger C, Haas J
Department of Dermatology and Venereology, Medical University of Graz, Austria.
J Wound Care. 2005 Sep;14(8):391-4. doi: 10.12968/jowc.2005.14.8.26825.
Venous leg ulcer treatment often requires months or years of regular wound care by trained staff. It has been suggested that low-level laser irradiation has a biostimulative and wound healing effect, but this has not been clinically verified by controlled studies. This study aimed to compare the effectiveness of low-level laser irradiation with that of a placebo 'light source'.
Forty-four patients were assigned to two treatment groups (laser and placebo) or a third group (standardised treatment only) to quantify the effect of the laser therapy. Patients in all three groups received standardised wound care (disinfection, a hydrofibre dressing and compression bandaging). Ulcer size was measured at baseline (day 1), at the end of therapy (day 28) and then two months later (day 90). The relative difference in wound size was evaluated.
The difference in the reduction in wound size was not statistically significant in all three groups. A positive effect of using the non-laser device (placebo effect) was demonstrated in some patients.
These study results suggest that low-level laser does not stimulate wound healing in venous leg ulcers. Further controlled studies are needed to clarify the efficacy of low-level laser treatment as a wound-healing stimulant.
下肢静脉性溃疡的治疗通常需要经过培训的工作人员进行数月或数年的定期伤口护理。有人提出低强度激光照射具有生物刺激和促进伤口愈合的作用，但这尚未得到对照研究的临床验证。本研究旨在比较低强度激光照射与安慰剂“光源”的效果。
44例患者被分为两个治疗组（激光组和安慰剂组）或第三组（仅接受标准化治疗），以量化激光治疗的效果。所有三组患者均接受标准化伤口护理（消毒、水凝胶敷料和加压包扎）。在基线（第1天）、治疗结束时（第28天）以及两个月后（第90天）测量溃疡大小。评估伤口大小的相对差异。
三组患者伤口大小减小的差异无统计学意义。在一些患者中显示出使用非激光设备的积极效果（安慰剂效应）。
这些研究结果表明，低强度激光并不能刺激下肢静脉性溃疡的伤口愈合。需要进一步的对照研究来阐明低强度激光治疗作为伤口愈合刺激剂的疗效。
