Hettlich Bianca E, Boothe Harry W, Simpson R Bruce, Dubose Kim A, Boothe Dawn M, Carpenter Mark
Department of Veterinary Small Animal Medicine, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.
J Am Vet Med Assoc. 2005 Sep 1;227(5):748-55. doi: 10.2460/javma.2005.227.748.
To evaluate differences in bacterial numbers, identity, and susceptibility in samples obtained from the tympanic cavity on entry (preflush) and after evacuation and lavage (postflush) and assess perioperative and empiric antimicrobial selection in dogs that underwent total ear canal ablation (TECA) with lateral bulla osteotomy (LBO) or reoperation LBO.
Prospective clinical study.
34 dogs.
TECA with LBO or reoperation LBO was performed on 47 ears. Pre- and postflush aerobic and anaerobic samples were obtained from the tympanic cavity. Isolates and antimicrobial susceptibility patterns were compared.
Different isolates (31/44 [70%] ears) and susceptibility patterns of isolate pairs (6/44 [14%] ears) were detected in pre- and postflush samples from 84% of ears. Evacuation and lavage of the tympanic cavity decreased the number of bacterial isolates by 33%. In 26% of ears, bacteria were isolated from post-flush samples but not preflush samples. Only 26% of isolates tested were susceptible to cefazolin. At least 1 isolate from 53% of dogs that received empirically chosen antimicrobials postoperatively was resistant to the selected drugs. Anaerobic bacteria were recovered from 6 ears.
Accurate microbiologic assessment of the tympanic cavity should be the basis for selection of antimicrobials in dogs undergoing TECA with LBO. Bacteria remain in the tympanic cavity after evacuation and lavage. Cefazolin was a poor choice for dogs that underwent TECA with LBO, as judged on the basis of culture and susceptibility testing results.
评估在进行全耳道切除术（TECA）并伴有侧鼓室切开术（LBO）或再次手术LBO的犬只中，从鼓室获取的进入时（冲洗前）和排空及灌洗后（冲洗后）样本的细菌数量、种类及药敏性差异，并评估围手术期和经验性抗菌药物的选择。
前瞻性临床研究。
34只犬。
对47只耳朵进行了TECA并伴有LBO或再次手术LBO。从鼓室获取冲洗前和冲洗后的需氧和厌氧样本。比较分离菌及抗菌药敏模式。
在84%的耳朵冲洗前和冲洗后的样本中检测到不同的分离菌（31/44 [70%]只耳朵）和分离菌对的药敏模式（6/44 [14%]只耳朵）。鼓室的排空和灌洗使细菌分离数量减少了33%。在26%的耳朵中，冲洗后样本中分离出细菌，但冲洗前样本中未分离出。仅26%的检测分离菌对头孢唑林敏感。在术后接受经验性选择抗菌药物的犬只中，53%的犬至少有1株分离菌对所选药物耐药。从6只耳朵中分离出厌氧菌。
对进行TECA并伴有LBO的犬只，鼓室准确的微生物学评估应作为抗菌药物选择的依据。排空和灌洗后细菌仍残留在鼓室中。根据培养和药敏试验结果判断，头孢唑林对于进行TECA并伴有LBO的犬不是一个好的选择。
