基因表达中的噪声：起源、影响及调控
Noise in gene expression: origins, consequences, and control.
作者信息
Raser Jonathan M, O'Shea Erin K
机构信息
Medical Scientist Training Program, University of California-San Francisco, 600 16th Street, GH-S472D, San Francisco, CA 94143-2240, USA.
出版信息
Science. 2005 Sep 23;309(5743):2010-3. doi: 10.1126/science.1105891.
Abstract
Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation, in the process of gene expression may contribute to this phenotypic variability. Recent studies suggest that this noise has multiple sources, including the stochastic or inherently random nature of the biochemical reactions of gene expression. In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression.
摘要
基因相同的细胞和生物体即使有着相同的环境暴露历史，仍表现出显著的多样性。基因表达过程中的噪音或变异可能导致这种表型变异性。最近的研究表明，这种噪音有多种来源，包括基因表达生化反应的随机性或内在的随机性。在这篇综述中，我们总结了噪音术语，并对最近关于基因表达中噪音的来源、后果及控制的研究进行了评论。
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