Rixen D, Sauerland S, Oestern H-J, Bouillon B
Klinik für Unfallchirurgie, Lehrstuhl der Universität Witten/Herdecke, Klinikum Köln-Merheim.
Unfallchirurg. 2005 Oct;108(10):829-38, 840-2. doi: 10.1007/s00113-005-1012-2.
Lower extremity injuries make up a substantial proportion of the injuries in multiply injured patients. The aim of this systematic literature analysis was to give an overview of the levels of evidence for different management strategies in the first operative phase after long-bone injuries of the lower extremity in multiply injured patients to enable, in the presence of adequate evidence, the development of clinical management corridors or, if the evidence was found to be inadequate, to document the necessity for scientific proof.
Clinical trials were systematically collected (Medline, Cochrane and hand searches) and classified into evidence levels (EL 1 to 5 according to the Oxford system).
The necessity for primary or secondary definitive osteosynthesis of femur/tibia shaft fractures is still a matter of discussion. Intramedullary nailing is the preferred operative procedure for definitive treatment of femur shaft fractures. Stabilization of proximal and distal femur and tibia fractures is predominantly based on expert opinion. According to the literature, perioperative antibiotic prophylaxis is essential in fracture treatment.
Numerous comparative studies (EL 2) dealing with management strategies in the first operative phase after long-bone injuries of the lower extremity in multiply injured patients are available, but there are only a few randomized studies. Based on the available data, it is possible to develop a rational therapy for this patient population.
在多发伤患者中,下肢损伤占损伤的很大比例。本系统文献分析的目的是概述多发伤患者下肢长骨损伤后首次手术阶段不同治疗策略的证据水平,以便在有充分证据的情况下制定临床治疗路径,或者在证据不足时记录科学论证的必要性。
系统收集临床试验(通过医学文献数据库、考克兰系统评价数据库及手工检索)并根据牛津系统分为证据水平(EL 1至5级)。
股骨干/胫骨干骨折一期或二期确定性骨固定的必要性仍存在争议。髓内钉固定是股骨干骨折确定性治疗的首选手术方法。股骨近端和远端以及胫骨骨折的固定主要基于专家意见。根据文献,围手术期抗生素预防在骨折治疗中至关重要。
有许多关于多发伤患者下肢长骨损伤后首次手术阶段治疗策略的比较研究(EL 2级),但随机研究较少。基于现有数据,有可能为这一患者群体制定合理的治疗方案。