Frink Michael, Andruszkow Hagen, Zeckey Christian, Krettek Christian, Hildebrand Frank
Trauma Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
J Biomed Biotechnol. 2011;2011:797383. doi: 10.1155/2011/797383. Epub 2011 Jan 26.
Treatment of polytrauma patients remains a medical as well as socioeconomic challenge. Although diagnostics and therapy improved during the last decades, multiple injuries are still the major cause of fatalities in patients below 45 years of age. Organ dysfunction and organ failure are major complications in patients with major injuries and contribute to mortality during the clinical course. Profound understanding of the systemic pathophysiological response is crucial for innovative therapeutic approaches. Therefore, experimental studies in various animal models are necessary. This review is aimed at providing detailed information of common trauma models in small as well as in large animals.
多发伤患者的治疗仍然是一项医学和社会经济挑战。尽管在过去几十年中诊断和治疗有所改善，但多发伤仍是45岁以下患者死亡的主要原因。器官功能障碍和器官衰竭是重伤患者的主要并发症，并在临床过程中导致死亡。深刻理解全身病理生理反应对于创新治疗方法至关重要。因此，有必要在各种动物模型中进行实验研究。本综述旨在提供关于小型和大型动物常见创伤模型的详细信息。
