Hammann A, Arveux P, Martin M
INSERM U. 252, Faculty of Medicine, University of Dijon, France.
Dig Dis Sci. 1992 Jul;37(7):1099-104. doi: 10.1007/BF01300293.
In previous studies, chemically induced colonic carcinomas were found to originate preferentially from crypts adjacent to lymphoid tissue. Proliferative parameters and mucosecretion were analyzed in proximal and distal rat colon in relation to the proximity of lymphoid patches. Animals received an intraperitoneal pulse of bromodeoxyuridine 1-hr before death. In both proximal and distal colon, crypts located at the immediate proximity of the lymphoid formations contained fewer mucous cells (P less than 0.001), but a higher percentage of proliferative epithelial cells (P less than 0.001) than the crypts far from lymphoid formations. The labeling index was higher in crypts adjacent to lymphoid patches compared to crypts distant from lymphoid patches only in the lower third of the crypts. The association of an increased proliferative activity and a decrease in differentiated mucosecreting cells in colonic crypts adjacent to lymphoid patches could be related to the particular sensitivity of these crypts cells to the effects of mutagens and carcinogens.
在先前的研究中，发现化学诱导的结肠癌优先起源于邻近淋巴组织的隐窝。分析了大鼠近端和远端结肠的增殖参数和黏液分泌与淋巴集结 proximity 的关系。动物在死亡前 1 小时接受腹腔注射溴脱氧尿苷脉冲。在近端和远端结肠中，紧邻淋巴组织的隐窝所含黏液细胞较少（P < 0.001），但与远离淋巴组织的隐窝相比，增殖上皮细胞的百分比更高（P < 0.001）。仅在隐窝的下三分之一处，与远离淋巴集结的隐窝相比，紧邻淋巴集结的隐窝的标记指数更高。紧邻淋巴集结的结肠隐窝中增殖活性增加与分化的黏液分泌细胞减少之间的关联可能与这些隐窝细胞对诱变剂和致癌物作用的特殊敏感性有关。
