Uematsu Yoko, Ogimoto Mami, Kabashima Junichiro, Suzuki Kumi, Kaneko Reiko, Funayama Keiichi, Haneishi Nahoko, Yasuno Tetsuko, Ogino Shuzo
The Tokyo Metropolitan Institute of Public Healt, 3-24-1, Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan.
Shokuhin Eiseigaku Zasshi. 2005 Aug;46(4):133-8. doi: 10.3358/shokueishi.46.133.
Migration from multi-layer laminated film pouches intended for retort foods was investigated through HPLC analysis with a fluorescence detector, and measurements of residue on evaporation, consumption of potassium permanganate and total organic carbon. HPLC analysis revealed that the levels of migrants in oil and the water which were heated in the pouches (121 degrees C, 30 min) were ten times of those in the corresponding official simulants under the official conditions; n-heptane (25 degrees C, 60 min), and water (95 degrees C, 30 min). Bisphenol A diglycidyl ether and related compounds were found in the oil and the water heated in the pouches, as well as in the simulants. These compounds were thought to have been present in the adhesive between the laminated films, and migrated through the food-contact film of the package. Consumption of potassium permanganate and residue on evaporation of the heated water were ten times of those of the water simulant, while the total organic carbon level of the heated water was several-hold greater than that of the water simulant. In addition, migrant levels per surface area of the pouch were one-fourth of the concentrations per content volume of the pouch. Since compliance with the legal limits is evaluated based on the concentration per surface area, real migration into foods would be underestimated by a factor of another four.
通过配备荧光检测器的高效液相色谱（HPLC）分析、蒸发残渣测定、高锰酸钾消耗量测定以及总有机碳测定，对用于高温杀菌食品的多层复合薄膜袋的迁移情况进行了研究。HPLC分析表明，在袋中加热（121℃，30分钟）的油和水中的迁移物水平是在官方条件下相应官方模拟物中的十倍；正庚烷（25℃，60分钟）和水（95℃，30分钟）。在袋中加热的油和水中以及模拟物中均发现了双酚A二缩水甘油醚及相关化合物。这些化合物被认为存在于复合薄膜之间的粘合剂中，并通过包装的食品接触膜迁移。加热水的高锰酸钾消耗量和蒸发残渣是水模拟物的十倍，而加热水的总有机碳水平比水模拟物高出几倍。此外，每袋表面积的迁移物水平是每袋内容物体积浓度的四分之一。由于是根据每表面积的浓度来评估是否符合法定限量，因此实际向食品中的迁移量会被低估四倍。
