Mruk Dolores D, Lau Ann S N, Conway Anne M
Population Council, Center for Biomedical Research 1230 York Ave., New York, NY 10021, USA.
Contraception. 2005 Oct;72(4):280-90. doi: 10.1016/j.contraception.2005.03.013.
For the past several years, studies from other laboratories, as well as ours, have begun to unravel the mechanism of germ cell movement in the testis by using several in vitro and in vivo models of tight and adherens junction assembly and disassembly, two cellular phenomena that confer cell movement. However, for cell movement to be fully appreciated, the importance of "intracellular" cell movements, such as those involving actin and microtubule filaments, must be better understood. Recent research on Rab GTPases has shown that members of this superfamily function in the trafficking of vesicles containing cargo to distinct subcellular sites such as the plasma membrane while utilizing actin and microtubule filaments as tracks. In this mini-review, we provide an overview of Rab GTPase structure, function, and regulation, while placing added emphasis on the role of Rabs in cell junction dynamics in the testis.
在过去几年中，其他实验室以及我们实验室的研究，已开始通过使用紧密连接和黏附连接组装与拆卸的多种体外和体内模型来揭示睾丸中生殖细胞运动的机制，这两种细胞现象赋予了细胞运动能力。然而，要全面理解细胞运动，就必须更好地了解“细胞内”细胞运动的重要性，比如那些涉及肌动蛋白和微管丝的运动。近期对Rab GTP酶的研究表明，这个超家族的成员在将含有货物的囊泡运输到不同亚细胞位点（如质膜）的过程中发挥作用，同时利用肌动蛋白和微管丝作为轨道。在这篇小型综述中，我们概述了Rab GTP酶的结构、功能和调控，同时特别强调了Rabs在睾丸细胞连接动态变化中的作用。
