肺血栓栓塞症猝死：时间生物学方面

Sudden death from pulmonary thromboembolism: chronobiological aspects.

作者信息

Gallerani M, Manfredini R, Ricci L, Grandi E, Cappato R, Calò G, Pareschi P L, Fersini C

机构信息

Institute of Internal Medicine, University of Ferrara, Italy.

出版信息

Eur Heart J. 1992 May;13(5):661-5. doi: 10.1093/oxfordjournals.eurheartj.a060232.

DOI:10.1093/oxfordjournals.eurheartj.a060232

PMID:1618210

Abstract

The aim of this study was to determine whether sudden cardiac death from pulmonary embolism exhibits any chronobiological rhythm. Five hundred and seven consecutive subjects dying suddenly outside of hospital and brought into our Emergency Department from January 1983 to December 1989 were studied. The time and date of event were accurately recorded. All subjects underwent autopsy and 48 of them were found to have died of pulmonary embolism (23 males, mean age 73.9 +/- 8 years and 25 females, mean age 76 +/- 12 years). All data were analysed by means of single cosinor[19,20]. In the subjects with pulmonary emboli both a circadian and a circannual rhythmicity were found, with a significant acrophase respectively in the morning (h.min. 11.46, P = 0.003) and in winter (-19.3, P = 0.009).

摘要

本研究的目的是确定肺栓塞导致的心源性猝死是否呈现任何时间生物学节律。对1983年1月至1989年12月期间连续507例在院外突然死亡并被送至我院急诊科的患者进行了研究。准确记录了事件发生的时间和日期。所有患者均接受了尸检，其中48例被发现死于肺栓塞（男性23例，平均年龄73.9±8岁；女性25例，平均年龄76±12岁）。所有数据均采用单余弦分析法进行分析[19,20]。在肺栓塞患者中，发现了昼夜节律和年节律，其峰值相位分别在上午（小时.分钟 11.46，P = 0.003）和冬季（-19.3，P = 0.009）。