训练大鼠的脂质代谢：瓜拉那（巴西香可可）补充剂的作用。

Lipid metabolism in trained rats: effect of guarana (Paullinia cupana Mart.) supplementation.

作者信息

Lima Waldecir P, Carnevali Luiz C, Eder Robson, Costa Rosa Luis Fernando B P, Bacchi Elfriede M, Seelaender Marília C L

机构信息

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Av. Prof. Lineu Prestes 1524, São Paulo, SP, CEP 05508-900, Brazil.

出版信息

Clin Nutr. 2005 Dec;24(6):1019-28. doi: 10.1016/j.clnu.2005.08.004. Epub 2005 Sep 22.

DOI:10.1016/j.clnu.2005.08.004

PMID:16182414

Abstract

BACKGROUND AND AIMS

Guarana is widely consumed by athletes, either in supplements or in soft drinks, under the belief that it presents ergogenic and "fat burning" effects. We examined the effect of guarana supplementation (14 days) upon aspects of lipid metabolism in sedentary (C) and trained rats (T).

METHODS

To isolate the effect of caffeine from that of other components of guarana, we adopted two different doses of whole extract (G1-0.130 g/kg; G2-0.325 g/kg) or decaffeinated extract (DG1, DG2). Body weight, food and water intake; muscle fat content, oleate incorporation, glycogen content, and carnitine palmitoyltransferase I (CPT I) activity and mRNA expression; along with plasma lactate concentration, were assessed.

RESULTS

Muscle oleate incorporation was decreased in rats receiving decaffeinated guarana in relation to G1 and G2; as was CPT I mRNA expression in the gastrocnemius. Whole extract supplementation, but not DG induced reduced plasma lactate concentration in trained rats. G1 showed higher muscle glycogen content compared with all other groups. The results show an effect of guarana on aspects of lipid metabolism, which is abolished by decaffeination.

CONCLUSION

The changes in lipid metabolism of supplemented rats herein reported are associated with the methylxanthine content of guarana.

摘要

背景与目的

瓜拉那被运动员广泛食用，无论是以补充剂形式还是添加在软饮料中，因为人们认为它具有提高运动能力和“燃烧脂肪”的作用。我们研究了补充瓜拉那（14天）对久坐不动的大鼠（C组）和经过训练的大鼠（T组）脂质代谢各方面的影响。

方法

为了分离咖啡因与瓜拉那其他成分的作用，我们采用了两种不同剂量的全提取物（G1 - 0.130 g/kg；G2 - 0.325 g/kg）或脱咖啡因提取物（DG1、DG2）。评估了体重、食物和水的摄入量；肌肉脂肪含量、油酸掺入量、糖原含量、肉碱棕榈酰转移酶I（CPT I）活性和mRNA表达；以及血浆乳酸浓度。