Maines Mahin D, Gibbs Peter E M
University of Rochester Medical Center, Department of Biochemistry and Biophysics, 601 Elmwood Avenue Rochester, NY 14624, USA.
Biochem Biophys Res Commun. 2005 Dec 9;338(1):568-77. doi: 10.1016/j.bbrc.2005.08.121. Epub 2005 Aug 24.
In the beginning, the microsomal HO system was presumed to be made of one isozymes, now known as HO-1, which was cytP450-dependent; and, was thought to be of physiological significance solely in the context of catalysis of hemoglobin heme to bile pigments and CO. A succession of discoveries including characterization of the system as an independent mono-oxygenase, identification of a second form, called HO-2, free radical quenching activity of bile pigments, analogous function of CO in cell signaling to NO, and characterization of the system as HSP32 cognates has led to such an impressive expansion in the number of reports dealing with the HO system that surpass anyone's expectation. This review is a compilation of certain older findings and recent events that together ensure placement of the HO system in the mainstream research for decades to come.
起初，微粒体HO系统被认为由一种同工酶组成，即现在所知的HO-1，它依赖细胞色素P450；并且，当时认为其生理意义仅在于催化血红蛋白血红素生成胆色素和一氧化碳。一系列的发现，包括将该系统鉴定为一种独立的单加氧酶、鉴定出第二种形式即HO-2、胆色素的自由基淬灭活性、一氧化碳在细胞信号传导中与一氧化氮的类似功能，以及将该系统鉴定为热休克蛋白32同源物，使得关于HO系统的报道数量有了惊人的增长，超出了任何人的预期。这篇综述汇编了一些早期发现和近期事件，这些发现和事件共同确保了HO系统在未来几十年的主流研究中的地位。
