Telko Martin J, Hickey Anthony J
Division of Molecular Pharmaceutics, School of Pharmacy, CB# 7360, The University of North Carolina, Chapel Hill, North Carolina 27599, USA.
J Pharm Sci. 2007 Oct;96(10):2647-54. doi: 10.1002/jps.20897.
Inverse gas chromatography (IGC) has been employed as a research tool for decades. Despite this record of use and proven utility in a variety of applications, the technique is not routinely used in pharmaceutical research. In other fields the technique has flourished. IGC is experimentally relatively straightforward, but analysis requires that certain theoretical assumptions are satisfied. The assumptions made to acquire some of the recently reported data are somewhat modified compared to initial reports. Most publications in the pharmaceutical literature have made use of a simplified equation for the determination of acid/base surface properties resulting in parameter values that are inconsistent with prior methods. In comparing the surface properties of different batches of alpha-lactose monohydrate, new data has been generated and compared with literature to allow critical analysis of the theoretical assumptions and their importance to the interpretation of the data. The commonly used (simplified) approach was compared with the more rigorous approach originally outlined in the surface chemistry literature.
反相气相色谱法（IGC）作为一种研究工具已被使用了数十年。尽管有这样的使用记录且在各种应用中都证明了其效用，但该技术在药物研究中并未得到常规应用。在其他领域，该技术蓬勃发展。IGC在实验上相对简单，但分析需要满足某些理论假设。与最初的报告相比，为获取一些最近报道的数据所做的假设有所修改。药物文献中的大多数出版物都使用了一个简化方程来测定酸碱表面性质，导致参数值与先前方法不一致。在比较不同批次的一水合α-乳糖的表面性质时，生成了新的数据并与文献进行比较，以便对理论假设及其对数据解释的重要性进行批判性分析。将常用的（简化）方法与表面化学文献中最初概述的更严格方法进行了比较。
