Bonny Andrea E, Harkness Laura S, Cromer Barbara A
Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Adolesc Med Clin. 2005 Oct;16(3):569-84. doi: 10.1016/j.admecli.2005.05.006.
Depot medroxyprogesterone acetate (DMPA) is an effective and easy-to-use contraceptive method for adolescents. However, recent literature suggests that overweight teens may be at increased risk for weight gain while on this contraceptive method, and decreases in bone mineral density have been documented in adolescents on DMPA, particularly with longer duration of use. Consideration of this new literature on DMPA and its implications for clinical practice must be done in the context of the United States having the highest adolescent pregnancy rate in the industrialized world. Hence, potential DMPA risks need to be weighed against the risk of unintended pregnancy in an adolescent.
醋酸甲羟孕酮长效注射剂（DMPA）是一种对青少年有效且易于使用的避孕方法。然而，近期文献表明，超重青少年在使用这种避孕方法期间体重增加的风险可能会增加，并且已记录到使用DMPA的青少年骨矿物质密度下降，尤其是使用时间较长时。鉴于美国在工业化世界中青少年怀孕率最高，必须结合这一背景来考虑有关DMPA的这一新文献及其对临床实践的影响。因此，需要权衡DMPA的潜在风险与青少年意外怀孕的风险。
