Lüchtenborg Margreet, Weijenberg Matty P, de Goeij Anton F P M, Wark Petra A, Brink Mirian, Roemen Guido M J M, Lentjes Marjolein H F M, de Bruïne Adriaan P, Goldbohm R Alexandra, van 't Veer Pieter, van den Brandt Piet A
Department of Epidemiology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
Cancer Causes Control. 2005 Nov;16(9):1041-54. doi: 10.1007/s10552-005-0239-0.
The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer.
The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed.
Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression.
Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.
本研究旨在调查肉类和鱼类消费与结肠癌和直肠癌中APC突变状态及hMLH1表达之间的关联。
在荷兰队列研究中对这些关联进行调查，纳入了434例结肠癌患者和154例直肠癌患者，并对其进行病例-队列分析（子队列n = 2948）。
总肉类消费量与所研究的终点无关。肉类产品（即加工肉类）消费与携带截短型APC突变的结肠肿瘤呈正相关，而牛肉消费与无截短型APC突变的结肠肿瘤风险增加有关（摄入量最高四分位数与最低四分位数相比的发病率比值（RR）分别为1.61，95%置信区间（CI）0.96 - 2.71，p趋势 = 0.04；以及1.58，95%CI 1.10 - 2.25，p趋势 = 0.01）。其他肉类（马肉、羊肉、小牛肉、法兰克福香肠和炸肉卷）的消费与无截短型APC突变的直肠癌风险增加有关（摄入与未摄入相比的RR为1.79，95%CI 1.10 - 2.90）。未观察到肉类消费与缺乏hMLH1表达的肿瘤之间存在关联。
我们的数据表明，几种类型的肉类可能对结肠癌和直肠癌的病因学有不同的影响，这取决于肿瘤的APC突变状态而非hMLH1表达。
