Yin Wei, Gallocher Siobhain, Pinchuk Leonard, Schoephoerster Richard T, Jesty Jolyon, Bluestein Danny
Biomedical Engineering Department, Stony Brook University, NY 11794, USA.
Artif Organs. 2005 Oct;29(10):826-31. doi: 10.1111/j.1525-1594.2005.29109.x.
Polymer heart valves have been under investigation since the 1960s, but their success has been hampered by an overall lack of durability mainly due to calcification of the leaflets and a relatively high rate of thromboembolic complications. A new polymer (Quatromer) trileaflet design was tested for its thrombogenic potential and was compared to that of existing prosthetic heart valves routinely implanted in patients: a St. Jude Medical bileaflet mechanical heart valve (MHV) and a St. Jude porcine bioprosthetic tissue valve. The valves were mounted in a left ventricular assist device and the procoagulant activity of the platelets was measured using a platelet activation state (PAS) assay. The PAS measurements indicated that the platelet activation level induced by the polymeric valve was very similar to that induced by the St. Jude Medical MHV and the St. Jude tissue valve. No significant difference was observed between the three valves, indicating that they have a comparable thrombogenic potential.
自20世纪60年代以来，聚合物心脏瓣膜一直在研究中，但由于瓣叶钙化以及血栓栓塞并发症发生率相对较高，整体耐久性不足阻碍了其成功应用。一种新型聚合物（四聚体）三叶瓣设计对其血栓形成潜力进行了测试，并与常规植入患者体内的现有人工心脏瓣膜进行了比较：圣犹达医疗双叶机械心脏瓣膜（MHV）和圣犹达猪生物假体组织瓣膜。将这些瓣膜安装在左心室辅助装置中，并使用血小板活化状态（PAS）测定法测量血小板的促凝血活性。PAS测量表明，聚合物瓣膜诱导的血小板活化水平与圣犹达医疗MHV和圣犹达组织瓣膜诱导的水平非常相似。三种瓣膜之间未观察到显著差异，表明它们具有相当的血栓形成潜力。
