三叶型聚合物人工心脏瓣膜：发展与走向临床现实之路。
Polymeric trileaflet prosthetic heart valves: evolution and path to clinical reality.
机构信息
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
出版信息
Expert Rev Med Devices. 2012 Nov;9(6):577-94. doi: 10.1586/erd.12.51.
Abstract
Present prosthetic heart valves, while hemodynamically effective, remain limited by progressive structural deterioration of tissue valves or the burden of chronic anticoagulation for mechanical valves. An idealized valve prosthesis would eliminate these limitations. Polymeric heart valves (PHVs), fabricated from advanced polymeric materials, offer the potential of durability and hemocompatibility. Unfortunately, the clinical realization of PHVs to date has been hampered by findings of in vivo calcification, degradation and thrombosis. Here, the authors review the evolution of PHVs, evaluate the state of the art of this technology and propose a pathway towards clinical reality. In particular, the authors discuss the development of a novel aortic PHV that may be deployed via transcatheter implantation, as well as its optimization via device thrombogenicity emulation.
摘要
目前的人工心脏瓣膜在血液动力学上虽然有效，但仍受到组织瓣膜进行性结构恶化或机械瓣膜长期抗凝的限制。理想的瓣膜假体将消除这些限制。由先进的聚合物材料制成的聚合物心脏瓣膜（PHV）具有耐用性和血液相容性的潜力。不幸的是，迄今为止，PHV 的临床应用受到体内钙化、降解和血栓形成的影响。在这里，作者回顾了 PHV 的发展，评估了该技术的现状，并提出了通向临床现实的途径。特别是，作者讨论了一种新型主动脉 PHV 的开发，该瓣膜可通过经导管植入，以及通过设备血栓形成模拟对其进行优化。
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