负电荷气雾剂治疗慢性伤口的临床研究
Clinical study on the treatment of chronic wound with negatively-charged aerosol.
作者信息
Xie Xiaoxia, Chen Lei, Zhang Zhao-Qiang, Shi Yan, Xie Julin
机构信息
Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University Guangzhou, Guangdong, China.
出版信息
Int J Clin Exp Med. 2013 Sep 1;6(8):649-54. eCollection 2013.
BACKGROUND
Aerosols are defined as the mixture of liquid or solid particles/droplets that are stably suspending in air. When carrying a certain amount of negative charge, they will be defined as negatively-charged aerosol. This report investigates the effect of negatively-charged aerosol on the healing of chronic wound.
METHODS
140 patients with chronic wound were assigned randomly into two groups. Normal, routine treatment was applied on chronic wounds of 73 patients depending on wounds situation (control group). While another 67 similar patients received negatively-charged aerosol therapy (2 hours per time, twice a day) and were used as experimental group. Wound healing assessment including the patients' complication, detection of bacteria in wound secretions, and evaluation of wound healing.
RESULTS
The results of our study showed that after the application of negatively-charged aerosols, and condition and infection rate of wounds from experiment group were better and lower than that of control group. In comparison with control group, the relative size of wounds from experiment group was significantly smaller (P<0.05) at post-treatment day 0, 7, 14, 21 and 28. Also, the time required for wound healing in the experimental group was significantly shorter (P<0.05) than that in the control group.
CONCLUSION
Negatively-charged aerosol therapy can accelerate wound healing speed and improve the healing of chronic wounds. Thus, we wound recommend the consideration of Negatively-charged aerosol therapies in addition to normal wound treatment in cases of chronic wound.
背景
气溶胶被定义为稳定悬浮在空气中的液体或固体颗粒/液滴的混合物。当携带一定量的负电荷时，它们将被定义为带负电荷的气溶胶。本报告研究带负电荷的气溶胶对慢性伤口愈合的影响。
方法
140例慢性伤口患者被随机分为两组。根据伤口情况，对73例患者的慢性伤口进行常规治疗（对照组）。而另外67例类似患者接受带负电荷的气溶胶治疗（每次2小时，每天两次），作为实验组。伤口愈合评估包括患者并发症、伤口分泌物细菌检测和伤口愈合评估。
结果
我们的研究结果表明，应用带负电荷的气溶胶后，实验组伤口的状况和感染率均优于对照组且低于对照组。与对照组相比，实验组伤口在治疗后第0、7、14、21和28天的相对大小明显更小（P<0.05）。此外，实验组伤口愈合所需时间明显短于对照组（P<0.05）。
结论
带负电荷的气溶胶疗法可以加快伤口愈合速度，改善慢性伤口的愈合。因此，对于慢性伤口，除了常规伤口治疗外，我们建议考虑使用带负电荷的气溶胶疗法。
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