Doi Yasufumi, Kiyohara Yutaka, Kubo Michiaki, Ninomiya Toshiharu, Wakugawa Yoshiyuki, Yonemoto Koji, Iwase Masanori, Iida Mitsuo
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Diabetes Care. 2005 Oct;28(10):2497-500. doi: 10.2337/diacare.28.10.2497.
We examined the association between high-sensitivity C-reactive protein (CRP) levels and the development of diabetes in a general Japanese population.
A total of 1,759 Japanese subjects, aged 40-79 years and without diabetes (according to American Diabetes Association fasting criteria), were stratified into three groups according to CRP tertiles by sex and followed up prospectively for a mean of 9.0 years.
During the follow-up, 131 subjects (67 men and 64 women) developed diabetes. In both sexes, the age-adjusted cumulative incidence of diabetes increased significantly as the tertiles of CRP levels increased. In multivariate analyses, the risk of developing diabetes was significantly higher in the highest CRP tertile than in the lowest after adjustment for a number of confounding factors (odds ratio 2.63 [95% CI 1.23-5.65] for men and 2.25 [1.01-5.01] for women). In stratified analyses, this CRP-diabetes association was stronger in subjects without obesity or other risk factors related to insulin resistance and in nondrinking subjects.
Our findings suggest that elevated CRP concentration is a significant predictor of diabetes in the general Japanese population, independent of obesity and insulin resistance.
我们研究了日本普通人群中高敏C反应蛋白（CRP）水平与糖尿病发生之间的关联。
共有1759名年龄在40 - 79岁且无糖尿病（根据美国糖尿病协会空腹标准）的日本受试者，按性别根据CRP三分位数分为三组，并进行了平均9.0年的前瞻性随访。
在随访期间，131名受试者（67名男性和64名女性）患上了糖尿病。在两性中，随着CRP水平三分位数的增加，年龄调整后的糖尿病累积发病率显著上升。在多变量分析中，在调整了多个混杂因素后，CRP最高三分位数组患糖尿病的风险显著高于最低三分位数组（男性优势比2.63 [95% CI 1.23 - 5.65]，女性为2.25 [1.01 - 5.01]）。在分层分析中，这种CRP与糖尿病的关联在无肥胖或其他与胰岛素抵抗相关风险因素的受试者以及不饮酒的受试者中更强。
我们的研究结果表明，在日本普通人群中，CRP浓度升高是糖尿病的一个重要预测指标，独立于肥胖和胰岛素抵抗。
