McCarthy Florence O, Chopra Jay, Ford Alan, Hogan Sean A, Kerry Joe P, O'Brien Nora M, Ryan Eileen, Maguire Anita R
Department of Chemistry, School of Pharmacy, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland.
Org Biomol Chem. 2005 Aug 21;3(16):3059-65. doi: 10.1039/b505069c. Epub 2005 Jul 13.
Beta-sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.
β-谷甾醇是最普遍的植物胆固醇衍生物（植物甾醇），可经历与胆固醇类似的氧化过程，生成β-谷甾醇氧化物。植物甾醇氧化物的生物学影响仅在植物甾醇混合物（通常包含β-谷甾醇、菜油甾醇、豆甾醇和二氢油菜甾醇）中进行过评估。包括β-谷甾醇在内的纯植物甾醇的缺乏，阻碍了获取关于单个β-谷甾醇氧化物的大量毒性数据。本文描述了一种高效合成多克量纯β-谷甾醇的路线，以及纯β-谷甾醇氧化物的首次合成和表征。
