Mellies M J, Ishikawa T T, Glueck C J, Crissman J D
Cancer Res. 1977 Sep;37(9):3034-6.
Tissue phytosterol and cholesterol levels in 10 benign and 8 malignant breast tumors were quantitated to reexamine the hypothesis that malignant tumors had distinctive phytosterol content. Phytosterols were present in 9 of 10 benign and 7 of 8 malignant breast tumors. Mean (+/- S.E.) cholesterol, campesterol, stigmasterol, and beta-sitosterol in malignant and benign tumors (microgram/g wet weight) did not significantly differ (p greater than 0.1): (formula: see text) In the malignant tumors, tissue cholesterol correlated with campesterol (r = 0.97) and beta-sitosterol (r = 0.97) (p less than 0.01), but not stigmasterol (r = -0.06). In benign tumors, tissue cholesterol correlated with campesterol (r = 0.43), stigmasterol (r = 0.64), and beta-sitosterol (r = 0.94), with p less than 0.01 for the latter two. Phytosterols were present in four samples of normal breast tissue with mean (+/- S.E.) campesterol, stigmasterol, and beta-sitosterol (2 +/- 0.8, 15 +/- 9, 7 +/- 5 microgram/g wet weight) slightly but not significantly lower than in benign and malignant breast tumors, p greater than 0.1. The comparability of tissue phytosterols in benign and malignant breast tumors and in normal breast tissue appears to render unlikely and putative etiological relationship between phytosterols and breast carcinoma.
对10例良性乳腺肿瘤和8例恶性乳腺肿瘤中的组织植物甾醇和胆固醇水平进行了定量分析，以重新检验恶性肿瘤具有独特植物甾醇含量这一假设。10例良性乳腺肿瘤中有9例存在植物甾醇，8例恶性乳腺肿瘤中有7例存在植物甾醇。恶性肿瘤和良性肿瘤中胆固醇、菜油甾醇、豆甾醇和β-谷甾醇的平均（±标准误）含量（微克/克湿重）无显著差异（p>0.1）：（公式：见正文）在恶性肿瘤中，组织胆固醇与菜油甾醇（r = 0.97）和β-谷甾醇（r = 0.97）相关（p<0.01），但与豆甾醇不相关（r = -0.06）。在良性肿瘤中，组织胆固醇与菜油甾醇（r = 0.43）、豆甾醇（r = 0.64）和β-谷甾醇（r = 0.94）相关，后两者的p<0.01。在4份正常乳腺组织样本中存在植物甾醇，其菜油甾醇、豆甾醇和β-谷甾醇的平均（±标准误）含量（2±0.8、15±9、7±5微克/克湿重）略低于良性和恶性乳腺肿瘤，但无显著差异，p>0.1。良性和恶性乳腺肿瘤以及正常乳腺组织中组织植物甾醇的可比性似乎使得植物甾醇与乳腺癌之间不太可能存在假定的病因学关系。
