在日本人群中，α2cDel322 - 325、β1Ser49、β1Arg389肾上腺素能受体变体与心力衰竭风险之间无正相关。
No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population.
作者信息
Nonen Shinpei, Okamoto Hiroshi, Akino Masatoshi, Matsui Yutaka, Fujio Yasushi, Yoshiyama Minoru, Takemoto Yasuhiko, Yoshikawa Junichi, Azuma Junichi, Kitabatake Akira
机构信息
Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
出版信息
Br J Clin Pharmacol. 2005 Oct;60(4):414-7. doi: 10.1111/j.1365-2125.2005.02447.x.
AIMS
We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population.
METHODS
These polymorphisms were analysed by polymerase chain reaction-restriction fragment length polymorphism in patients with chronic heart failure due to idiopathic dilated cardiomyopathy (DCM) and compared with the control group.
RESULTS
There were no differences or any trends in the allele and genotype frequencies of the beta(1)Ser49Gly and beta(1)Arg389Gly polymorphisms. The allele frequency of the alpha(2c)Del322-325 variant was lower in patients than in controls (0.11 vs. 0.04, P = 0.011 < 0.017, by Bonferroni correction), while the genotype frequency just failed to reach significance (P = 0.022 > 0.017, by Bonferroni correction).
CONCLUSIONS
In this population, the variants beta(1)Ser49, beta(1)Arg389, and alpha(2c)Del322-325 do not appear to be risk factors for chronic heart failure due to DCM. The alpha(2c)Del322-325 variant may in fact confer some protection.
目的
我们研究了肾上腺素能受体基因多态性α（2c）Del322 - 325、β（1）Ser49Gly和β（1）Arg389Gly与日本人群心力衰竭风险的相关性。
方法
采用聚合酶链反应 - 限制性片段长度多态性方法分析特发性扩张型心肌病（DCM）所致慢性心力衰竭患者的这些基因多态性，并与对照组进行比较。
结果
β（1）Ser49Gly和β（1）Arg389Gly基因多态性的等位基因和基因型频率无差异或任何趋势。α（2c）Del322 - 325变异体的等位基因频率在患者中低于对照组（0.11对0.04，P = 0.011 < 0.017，经Bonferroni校正），而基因型频率刚未达到显著性水平（P = 0.022 > 0.017，经Bonferroni校正）。
结论
在该人群中，β（1）Ser49、β（1）Arg389和α（2c）Del322 - 325变异体似乎不是DCM所致慢性心力衰竭的危险因素。事实上，α（2c）Del322 - 325变异体可能具有一定的保护作用。
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