先天性心脏缺陷：死亡的患者。

Congenital heart defects: the patients who die.

作者信息

Meberg Alf, Lindberg Harald, Thaulow Erik

机构信息

Department of Paediatrics, Vestfold Hospital Tønsberg, Tønsberg, Norway.

出版信息

Acta Paediatr. 2005 Aug;94(8):1060-5. doi: 10.1111/j.1651-2227.2005.tb02046.x.

DOI:10.1111/j.1651-2227.2005.tb02046.x

PMID:16188850

Abstract

AIMS

To register mortality and causes of death in patients with congenital heart defects (CHDs).

METHODS

Prospective population-based observational study.

RESULTS

553 infants with CHD (1.1% of live born) were observed for 1-22 y (median 10 7/12 y). Sixty-four died (11.6%), of whom 32 (50%) died during the first 4 wk, and 51 (79.7%) during the first year of life. Of the total neonatal deaths in the population (3 per 1000), CHDs occurred in 21.5%. Mortality for children with CHDs was not significantly different between the cohorts born in 1982-1991 and 1992-2002, for either neonatal deaths or deaths later on (p>0.05). Out of 170 patients in whom therapeutic procedures (surgery, catheter interventions) were undertaken, 34 (20%) died. Nine cases (1.6%) died with unrecognized CHDs; seven of these on the first day of life with severe extracardiac malformations. In 50 (78.1%) cases, death was judged to be caused directly or indirectly from the CHD, and in 14 (21.9%) from extracardiac malformations or other conditions.

CONCLUSION

CHDs occur in a substantial number of neonatal deaths. Most deaths are caused by cardiac insufficiency. The mortality rate remained unchanged.

摘要

目的

登记先天性心脏病（CHD）患者的死亡率及死亡原因。

方法

基于人群的前瞻性观察性研究。

结果

对553例先天性心脏病婴儿（占活产儿的1.1%）进行了1至22年的观察（中位时间为10又7/12年）。64例死亡（11.6%），其中32例（50%）在出生后前4周死亡，51例（79.7%）在1岁前死亡。在该人群的新生儿总死亡数中（每1000例中有3例），先天性心脏病占21.5%。1982 - 1991年出生队列和1992 - 2002年出生队列中，先天性心脏病患儿的死亡率在新生儿期死亡或之后死亡方面均无显著差异（p>0.05）。在接受治疗性手术（手术、导管介入）的170例患者中，34例（20%）死亡。9例（1.6%）死于未被识别的先天性心脏病；其中7例在出生第一天因严重的心外畸形死亡。在50例（78.1%）病例中，死亡被判定直接或间接由先天性心脏病导致，14例（21.9%）由心外畸形或其他情况导致。