Ma Marsha, Gauvreau Kimberlee, Allan Catherine K, Mayer John E, Jenkins Kathy J
Tufts University School of Medicine, Boston, Massachusetts, USA.
Ann Thorac Surg. 2007 Apr;83(4):1438-45. doi: 10.1016/j.athoracsur.2006.10.073.
There has been little research about the causes of death after congenital heart surgery.
To determine whether mode of death differs after congenital heart surgery, we evaluated the cause of death for 100 consecutive postoperative deaths at our institution. Mode of death was determined based on retrospective chart review including available autopsy reports. Low output states were categorized into ventricular failure; inadequate postoperative physiology (technically adequate surgery and ventricular function, but persistent low cardiac output); pulmonary hypertension; and atrioventricular valve regurgitation.
There was considerable anatomic diversity among patients who died; 46 patients had single-ventricle physiology. The vast majority of patients (n = 79) were in the intensive care unit before surgery. Surgical repairs were revised at initial operation in 22 cases; 7 patients died in the operating room. Seventy-three patients had technically adequate surgical procedures, 23 had residual anatomic defects, and 4 were indeterminate. Thirty patients underwent additional surgical and 9 catheter-based procedures, although some were classified as rescue procedures performed to address minor anatomic or physiologic abnormalities as a last hope to rescue the patient from impending demise. Of 100 deaths, most (n = 52) were due to low cardiac output: 24 inadequate postoperative physiology, 19 ventricular failure, 8 pulmonary hypertension, and 1 valvar regurgitation. Other significant causes of death included sudden cardiac arrest (n = 11), sepsis (n = 11), and procedural complications (n = 8).
More than half of the deaths were due to low cardiac output, but not exclusively ventricular failure.
关于先天性心脏病手术后的死亡原因,此前研究较少。
为确定先天性心脏病手术后的死亡方式是否存在差异,我们评估了本机构连续100例术后死亡病例的死因。死亡方式通过回顾病历记录(包括可用的尸检报告)来确定。低心排血量状态分为心室衰竭;术后生理功能不全(手术技术上合适且心室功能正常,但心排血量持续较低);肺动脉高压;以及房室瓣反流。
死亡患者的解剖结构存在很大差异;46例患者为单心室生理状态。绝大多数患者(n = 79)术前在重症监护病房。22例患者在初次手术时进行了手术修复;7例患者在手术室死亡。73例患者的手术操作在技术上是合适的,23例有残余解剖缺陷,4例情况不明。30例患者接受了额外的手术及9例导管介入手术,尽管有些被归类为挽救手术,是为解决轻微的解剖或生理异常而进行的最后一搏,以挽救患者免于即将到来的死亡。在100例死亡病例中,大多数(n = 52)是由于心排血量低:24例术后生理功能不全,19例心室衰竭,8例肺动脉高压,1例瓣膜反流。其他重要的死亡原因包括心脏骤停(n = 11)、败血症(n = 11)和手术并发症(n = 8)。
超过一半的死亡是由于心排血量低,但并非仅仅是心室衰竭所致。