卡波西肉瘤相关疱疹病毒病毒体诱导的ORF50立即早期启动子转录激活。
Kaposi's sarcoma-associated herpesvirus virion-induced transcription activation of the ORF50 immediate-early promoter.
作者信息
Lu Fang, Day Latasha, Lieberman Paul M
机构信息
The Wistar Institute, Philadelphia, PA 19104, USA.
出版信息
J Virol. 2005 Oct;79(20):13180-5. doi: 10.1128/JVI.79.20.13180-13185.2005.
Abstract
Lytic cycle reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) can be initiated by transcription activation of the ORF50 immediate-early (IE) gene promoter (ORF50p). We provide evidence that KSHV virions stimulate transcription of ORF50p. Virion activation was resistant to UV inactivation and cycloheximide treatment. The virion-responsive element was mapped to core promoter region -150 to + 1 relative to the ORF50 initiation codon. Electrophoretic mobility shift assays and chromatin immunoprecipitation suggest that KSHV virions indirectly alter the protein composition and chromatin modifications at ORF50p. These data suggest that KSHV virions possess an IE trans-inducing function similar to that observed in alpha- and betaherpesviruses.
摘要
卡波西肉瘤相关疱疹病毒（KSHV）的裂解周期重新激活可由ORF50立即早期（IE）基因启动子（ORF50p）的转录激活引发。我们提供的证据表明，KSHV病毒粒子可刺激ORF50p的转录。病毒粒子激活对紫外线灭活和放线菌酮处理具有抗性。病毒粒子反应元件被定位到相对于ORF50起始密码子的核心启动子区域-150至+1。电泳迁移率变动分析和染色质免疫沉淀表明，KSHV病毒粒子间接改变了ORF50p处的蛋白质组成和染色质修饰。这些数据表明，KSHV病毒粒子具有类似于在α和β疱疹病毒中观察到的IE反式诱导功能。
相似文献
1
Kaposi's sarcoma-associated herpesvirus virion-induced transcription activation of the ORF50 immediate-early promoter.卡波西肉瘤相关疱疹病毒病毒体诱导的ORF50立即早期启动子转录激活。
J Virol. 2005 Oct;79(20):13180-5. doi: 10.1128/JVI.79.20.13180-13185.2005.
2
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency.卡波西肉瘤相关疱疹病毒ORF50启动子的染色质重塑与潜伏激活相关。
J Virol. 2003 Nov;77(21):11425-35. doi: 10.1128/jvi.77.21.11425-11435.2003.
3
An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate.卡波西肉瘤相关疱疹病毒开放阅读框50启动子中的一个Sp1反应元件介导丁酸盐诱导的裂解周期。
J Virol. 2005 Feb;79(3):1397-408. doi: 10.1128/JVI.79.3.1397-1408.2005.
4
Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation.卡波西肉瘤相关疱疹病毒/人类疱疹病毒8型的ORF50/Rta蛋白与细胞蛋白八聚体-1及DNA的直接相互作用，对于确定延迟早期启动子的反式激活及刺激病毒激活至关重要。
J Virol. 2007 Aug;81(16):8451-67. doi: 10.1128/JVI.00265-07. Epub 2007 May 30.
5
6
Role of the cellular transcription factor YY1 in the latent-lytic switch of Kaposi's sarcoma-associated herpesvirus.细胞转录因子 YY1 在卡波西肉瘤相关疱疹病毒潜伏-裂解开关中的作用。
Virology. 2011 May 10;413(2):194-204. doi: 10.1016/j.virol.2011.02.013. Epub 2011 Mar 4.
7
X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency.X盒结合蛋白XBP-1s可反式激活卡波西肉瘤相关疱疹病毒（KSHV）的ORF50启动子，将浆细胞分化与KSHV从潜伏状态的重新激活联系起来。
J Virol. 2007 Dec;81(24):13578-86. doi: 10.1128/JVI.01663-07. Epub 2007 Oct 10.
8
Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter.靶向 dCas9 基转录激活子至 ORF50 启动子以激活卡波氏肉瘤相关疱疹病毒。
Viruses. 2020 Aug 27;12(9):952. doi: 10.3390/v12090952.
9
Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.NEDD8激活酶抑制剂MLN4924对卡波西肉瘤相关疱疹病毒裂解激活的影响。
J Virol. 2017 Sep 12;91(19). doi: 10.1128/JVI.00505-17. Print 2017 Oct 1.
10
De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists.从头合成蛋白质是爱泼斯坦-巴尔病毒裂解周期重新激活所必需的，但对于卡波西肉瘤相关疱疹病毒而言，在响应组蛋白脱乙酰酶抑制剂和蛋白激酶C激动剂时并非必需。
J Virol. 2007 Sep;81(17):9279-91. doi: 10.1128/JVI.00982-07. Epub 2007 Jun 27.
引用本文的文献
1
NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.NDRG1 通过与 DNA 聚合酶夹 PCNA 相互作用促进卡波西肉瘤相关疱疹病毒的复制和持续存在。
PLoS Pathog. 2019 Feb 27;15(2):e1007628. doi: 10.1371/journal.ppat.1007628. eCollection 2019 Feb.
2
Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage.内质网应激和半胱天冬酶依赖性RAD21裂解对卡波西肉瘤相关疱疹病毒潜伏构象的失调作用
PLoS Pathog. 2017 Aug 30;13(8):e1006596. doi: 10.1371/journal.ppat.1006596. eCollection 2017 Aug.
3
Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus.恒河猴疱疹病毒中LANA的破坏产生了一种高度裂解性的重组病毒。
J Virol. 2009 Oct;83(19):9786-802. doi: 10.1128/JVI.00704-09. Epub 2009 Jul 8.
4
Modulation of Kaposi's sarcoma-associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infection.原发性感染期间MEK/ERK、JNK和p38多条丝裂原活化蛋白激酶途径对卡波西肉瘤相关疱疹病毒感染和复制的调节作用
J Virol. 2006 Jun;80(11):5371-82. doi: 10.1128/JVI.02299-05.
本文引用的文献
1
Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.十四烷酰佛波醇乙酸酯诱导的AP1途径对卡波西肉瘤相关疱疹病毒RTA、RAP和MTA启动子的早期激活
J Virol. 2004 Apr;78(8):4248-67. doi: 10.1128/jvi.78.8.4248-4267.2004.
2
Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression.在原发性内皮细胞和成纤维细胞感染早期，卡波西肉瘤相关疱疹病毒同时表达具有免疫调节和抗凋亡功能的潜伏基因及有限数量的裂解基因，随后裂解基因表达下降。
J Virol. 2004 Apr;78(7):3601-20. doi: 10.1128/jvi.78.7.3601-3620.2004.
3
Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection.卡波西肉瘤相关疱疹病毒（KSHV/HHV-8）感染的内皮细胞、成纤维细胞和B细胞中的宿主基因诱导与转录重编程：对感染早期调控事件的见解
Cancer Res. 2004 Jan 1;64(1):72-84. doi: 10.1158/0008-5472.can-03-2767.
4
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.卡波西肉瘤相关疱疹病毒（KSHV）潜伏感染的低效建立表明持续的裂解性复制在卡波西肉瘤发病机制中具有额外作用。
J Clin Invest. 2004 Jan;113(1):124-36. doi: 10.1172/JCI17803.
5
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency.卡波西肉瘤相关疱疹病毒ORF50启动子的染色质重塑与潜伏激活相关。
J Virol. 2003 Nov;77(21):11425-35. doi: 10.1128/jvi.77.21.11425-11435.2003.
6
Productive lytic replication of a recombinant Kaposi's sarcoma-associated herpesvirus in efficient primary infection of primary human endothelial cells.重组卡波西肉瘤相关疱疹病毒在原代人内皮细胞高效初次感染中的生产性裂解复制
J Virol. 2003 Sep;77(18):9738-49. doi: 10.1128/jvi.77.18.9738-9749.2003.
7
Herpes simplex virus type 1 tegument protein VP22 interacts with TAF-I proteins and inhibits nucleosome assembly but not regulation of histone acetylation by INHAT.单纯疱疹病毒1型被膜蛋白VP22与TAF-I蛋白相互作用，并抑制核小体组装，但不抑制INHAT对组蛋白乙酰化的调控。
J Gen Virol. 2003 Sep;84(Pt 9):2501-2510. doi: 10.1099/vir.0.19326-0.
8
CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters.CCAAT/增强子结合蛋白α在卡波西肉瘤相关疱疹病毒（KSHV）裂解周期重新激活的早期阶段被诱导，并与KSHV复制和转录激活因子（RTA）协同刺激病毒的RTA、MTA和PAN启动子。
J Virol. 2003 Sep;77(17):9590-612. doi: 10.1128/jvi.77.17.9590-9612.2003.
9
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) infection of human fibroblast cells occurs through endocytosis.卡波西肉瘤相关疱疹病毒（人疱疹病毒8型）通过内吞作用感染人成纤维细胞。
J Virol. 2003 Jul;77(14):7978-90. doi: 10.1128/jvi.77.14.7978-7990.2003.
10
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.单纯疱疹病毒VP16诱导复合物：调控开关的构成要素
Trends Biochem Sci. 2003 Jun;28(6):294-304. doi: 10.1016/S0968-0004(03)00088-4.
Zotero 插件