鲍曼不动杆菌天然存在的苯唑西林酶的特性研究。
Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii.
作者信息
Héritier Claire, Poirel Laurent, Fournier Pierre-Edouard, Claverie Jean-Michel, Raoult Didier, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2005 Oct;49(10):4174-9. doi: 10.1128/AAC.49.10.4174-4179.2005.
Abstract
A chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. beta-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species.
摘要
从鲍曼不动杆菌AYE中鉴定出一种染色体编码的苯唑西林酶OXA-69。β-内酰胺酶OXA-69与最近描述的鲍曼不动杆菌OXA-51酶具有97%的氨基酸同一性，与碳青霉烯水解苯唑西林酶OXA-24和OXA-23分别具有62%和56%的氨基酸同一性。纯化的OXA-69的生化特性显示出窄谱水解谱，但包括低水平的亚胺培南和美罗培南。通过PCR和测序，在所有测试的鲍曼不动杆菌菌株（n = 12）中鉴定出bla(OXA-69)样基因，表明该苯唑西林酶在该菌种中天然存在。
相似文献
1
Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii.鲍曼不动杆菌天然存在的苯唑西林酶的特性研究。
Antimicrob Agents Chemother. 2005 Oct;49(10):4174-9. doi: 10.1128/AAC.49.10.4174-4179.2005.
2
OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.OXA-58，一种新型的D类β-内酰胺酶，与鲍曼不动杆菌对碳青霉烯类抗生素的耐药性有关。
Antimicrob Agents Chemother. 2005 Jan;49(1):202-8. doi: 10.1128/AAC.49.1.202-208.2005.
3
Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii.获得性碳青霉烯水解型苯唑西林酶对鲍曼不动杆菌碳青霉烯耐药性的作用。
Antimicrob Agents Chemother. 2005 Aug;49(8):3198-202. doi: 10.1128/AAC.49.8.3198-3202.2005.
4
Carbapenem-hydrolyzing oxacillinase in high resistant strains of Acinetobacter baumannii isolated from India.印度分离的高产碳青霉烯酶鲍曼不动杆菌高耐药株中的碳青霉烯酶水解青霉素酶。
Microb Pathog. 2012 Aug;53(2):81-6. doi: 10.1016/j.micpath.2012.05.004. Epub 2012 May 17.
5
OXA-235, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.鲍曼不动杆菌碳青霉烯类耐药中涉及的一种新型 D 类β-内酰胺酶 OXA-235。
Antimicrob Agents Chemother. 2013 May;57(5):2121-6. doi: 10.1128/AAC.02413-12. Epub 2013 Feb 25.
6
Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.抗辐射不动杆菌作为不动杆菌属碳青霉烯耐药性的隐匿来源
Antimicrob Agents Chemother. 2008 Apr;52(4):1252-6. doi: 10.1128/AAC.01304-07. Epub 2008 Jan 14.
7
Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina.对OXA-51的特性描述，OXA-51是在来自阿根廷的鲍曼不动杆菌无亲缘关系临床菌株中发现的一种新型D类碳青霉烯酶。
Clin Microbiol Infect. 2005 Jan;11(1):15-23. doi: 10.1111/j.1469-0691.2004.01016.x.
8
Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii.多拷贝blaOXA-58基因作为鲍曼不动杆菌对碳青霉烯类高水平耐药的来源。
Antimicrob Agents Chemother. 2007 Jul;51(7):2324-8. doi: 10.1128/AAC.01502-06. Epub 2007 Apr 16.
9
Identification of the naturally occurring genes encoding carbapenem-hydrolysing oxacillinases from Acinetobacter haemolyticus, Acinetobacter johnsonii, and Acinetobacter calcoaceticus.从溶血不动杆菌、约翰逊不动杆菌和醋酸钙不动杆菌中鉴定出天然存在的碳青霉烯水解型青霉素酶基因。
Clin Microbiol Infect. 2012 Sep;18(9):907-13. doi: 10.1111/j.1469-0691.2011.03708.x. Epub 2011 Nov 30.
10
OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.鲍曼不动杆菌中的新型碳青霉烯水解酶 OXA-143。
Antimicrob Agents Chemother. 2009 Dec;53(12):5035-8. doi: 10.1128/AAC.00856-09. Epub 2009 Sep 21.
引用本文的文献
1
Detection of a new bla variant (bla) and a novel sequence type (ST3457/2790) in Acinetobacter baumannii isolated from community sewage and an incinerator surface in Nigeria.在从尼日利亚社区污水和焚烧炉表面分离出的鲍曼不动杆菌中检测到一种新的bla变体（bla）和一种新的序列类型（ST3457/2790）。
BMC Res Notes. 2025 Aug 6;18(1):345. doi: 10.1186/s13104-025-07384-z.
2
Emergence of carbapenem-resistant clonal complex 2 in multiple hospitals in São Paulo state, Brazil.巴西圣保罗州多家医院中耐碳青霉烯类的克隆复合体2的出现。
Antimicrob Agents Chemother. 2025 Sep 3;69(9):e0186524. doi: 10.1128/aac.01865-24. Epub 2025 Jul 23.
3
1-(1-naphthylmethyl)-piperazine Inhibition assay successfully rules out efflux pump overexpression in Acinetobacter baumannii.1-（1-萘甲基）-哌嗪抑制试验成功排除了鲍曼不动杆菌中流出泵的过表达。
Mol Biol Rep. 2025 Jul 18;52(1):736. doi: 10.1007/s11033-025-10826-3.
4
Local Genomic Epidemiology of Acinetobacter baumannii Circulating in Hospital and Non-hospital Environments in Kano, Northwest Nigeria.尼日利亚西北部卡诺地区医院和非医院环境中传播的鲍曼不动杆菌的局部基因组流行病学
Curr Microbiol. 2025 Jun 8;82(7):329. doi: 10.1007/s00284-025-04304-z.
5
Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant AYE.RND超家族多药外排泵AdeABC、AdeFGH和AdeIJK对多重耐药AYE菌株抗菌耐药性及毒力因子的作用
Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0185824. doi: 10.1128/aac.01858-24. Epub 2025 May 23.
6
Insights into AMA205's Unprecedented Antibiotic Resistance.深入了解 AMA205 抗生素耐药性的突破性进展
Int J Mol Sci. 2024 Oct 24;25(21):11424. doi: 10.3390/ijms252111424.
7
The context of bla gene in Iraqi carbapenem-resistant Acinetobacter baumannii isolates belonging to global clone 1 and global clone 2.伊拉克碳青霉烯类耐药鲍曼不动杆菌分离株 bla 基因的全球克隆 1 和全球克隆 2 背景。
BMC Res Notes. 2024 Oct 8;17(1):300. doi: 10.1186/s13104-024-06890-w.
8
Alteration in the Morphological and Transcriptomic Profiles of after Exposure to Colistin.暴露于黏菌素后[具体对象]的形态学和转录组学特征改变。 （注：原文中“of”后面缺少具体内容）
Microorganisms. 2024 Aug 11;12(8):1644. doi: 10.3390/microorganisms12081644.
9
Evaluating the antibacterial effect of meropenem-loaded chitosan/sodium tripolyphosphate (TPP) nanoparticles on Acinetobacter baumannii isolated from hospitalized patients.评价载美罗培南壳聚糖/三聚磷酸钠（TPP）纳米粒对住院患者分离鲍曼不动杆菌的抗菌效果。
BMC Infect Dis. 2024 Jun 24;24(1):631. doi: 10.1186/s12879-024-09522-7.
10
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR.细胞外 ATP 介导电泳大肠癌进展的分子机制：嘌呤能受体介导 HuR 的核质穿梭的意义。
Purinergic Signal. 2024 Dec;20(6):669-680. doi: 10.1007/s11302-024-10021-2. Epub 2024 May 27.
本文引用的文献
1
ARI 1: beta-lactamase-mediated imipenem resistance in Acinetobacter baumannii.鲍曼不动杆菌中β-内酰胺酶介导的碳青霉烯类耐药性。
Int J Antimicrob Agents. 1993 Feb;2(2):81-7. doi: 10.1016/0924-8579(93)90045-7.
2
Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii.鲍曼不动杆菌中因ISAba1插入导致头孢菌素酶过表达。
Clin Microbiol Infect. 2006 Feb;12(2):123-30. doi: 10.1111/j.1469-0691.2005.01320.x.
3
Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii.获得性碳青霉烯水解型苯唑西林酶对鲍曼不动杆菌碳青霉烯耐药性的作用。
Antimicrob Agents Chemother. 2005 Aug;49(8):3198-202. doi: 10.1128/AAC.49.8.3198-3202.2005.
4
The sequences of seven class D beta-lactamases isolated from carbapenem-resistant Acinetobacter baumannii from four continents.从四大洲耐碳青霉烯类鲍曼不动杆菌中分离出的七种D类β-内酰胺酶的序列。
Clin Microbiol Infect. 2005 Apr;11(4):326-9. doi: 10.1111/j.1469-0691.2005.01096.x.
5
Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina.对OXA-51的特性描述，OXA-51是在来自阿根廷的鲍曼不动杆菌无亲缘关系临床菌株中发现的一种新型D类碳青霉烯酶。
Clin Microbiol Infect. 2005 Jan;11(1):15-23. doi: 10.1111/j.1469-0691.2004.01016.x.
6
OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.OXA-58，一种新型的D类β-内酰胺酶，与鲍曼不动杆菌对碳青霉烯类抗生素的耐药性有关。
Antimicrob Agents Chemother. 2005 Jan;49(1):202-8. doi: 10.1128/AAC.49.1.202-208.2005.
7
Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium.不动杆菌ADP1的基因组序列揭示的独特特征，ADP1是一种具有多种功能且天然具备转化能力的细菌。
Nucleic Acids Res. 2004 Oct 28;32(19):5766-79. doi: 10.1093/nar/gkh910. Print 2004.
8
OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii.OXA-60，一种来自皮氏罗尔斯通氏菌的染色体介导的、可诱导的、能水解亚胺培南的D类β-内酰胺酶。
Antimicrob Agents Chemother. 2004 Nov;48(11):4217-25. doi: 10.1128/AAC.48.11.4217-4225.2004.
9
Acinetobacter baumannii in human body louse.人体虱子中的鲍曼不动杆菌。
Emerg Infect Dis. 2004 Sep;10(9):1671-3. doi: 10.3201/eid1009.040242.
10
Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system.鲍曼不动杆菌中RND型外排泵AdeABC的表达受双组分系统AdeRS调控。
Antimicrob Agents Chemother. 2004 Sep;48(9):3298-304. doi: 10.1128/AAC.48.9.3298-3304.2004.
Zotero 插件