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本文引用的文献

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Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid.抗菌药物的基本药效学及其在β-内酰胺类、糖肽类和利奈唑胺临床应用中的情况。
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An evidence-based approach to diabetic foot infections.一种基于证据的糖尿病足感染治疗方法。
Am J Surg. 2003 Nov 28;186(5A):44S-54S; discussion 61S-64S. doi: 10.1016/j.amjsurg.2003.10.008.
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Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans.莫西沙星在人体健康及炎症状态下皮下脂肪组织中的渗透情况。
Antimicrob Agents Chemother. 2003 Oct;47(10):3099-103. doi: 10.1128/AAC.47.10.3099-3103.2003.
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Penetration of piperacillin and tazobactam into pneumonic human lung tissue measured by in vivo microdialysis.通过体内微透析测定哌拉西林和他唑巴坦在人肺炎肺组织中的渗透情况。
Br J Clin Pharmacol. 2003 Jun;55(6):620-4. doi: 10.1046/j.1365-2125.2003.01797.x.
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Diabetic foot ulcers.糖尿病足溃疡
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Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome.磷霉素在蜂窝织炎或糖尿病足综合征患者炎症病灶中的渗透情况。
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Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients.环丙沙星在非胰岛素依赖型糖尿病患者足部炎症性病变间质中的渗透情况。
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Piperacillin/tazobactam: an updated review of its use in the treatment of bacterial infections.哌拉西林/他唑巴坦：其在治疗细菌感染中的应用最新综述
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哌拉西林和他唑巴坦在糖尿病足感染患者炎症性软组织中的渗透情况。

Penetration of piperacillin and tazobactam into inflamed soft tissue of patients with diabetic foot infection.

作者信息

Legat F J, Krause R, Zenahlik P, Hoffmann C, Scholz S, Salmhofer W, Tscherpel J, Tscherpel T, Kerl H, Dittrich P

机构信息

Department of Dermatology, Division of Infectious Diseases, Medical University of Graz, Austria.

出版信息

Antimicrob Agents Chemother. 2005 Oct;49(10):4368-71. doi: 10.1128/AAC.49.10.4368-4371.2005.

DOI:10.1128/AAC.49.10.4368-4371.2005
PMID:16189124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1251535/
Abstract

We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue.

摘要

我们使用体内微透析技术，研究了哌拉西林和他唑巴坦在6例糖尿病足感染患者发炎软组织细胞外液中的药代动力学，发现哌拉西林在发炎和未发炎软组织中的渗透情况相似，但他唑巴坦并非如此。