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磷霉素在蜂窝织炎或糖尿病足综合征患者炎症病灶中的渗透情况。

Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome.

作者信息

Legat F J, Maier A, Dittrich P, Zenahlik P, Kern T, Nuhsbaumer S, Frossard M, Salmhofer W, Kerl H, Müller M

机构信息

Department of Dermatology, Division of Thoracic and Hyperbaric Surgery, Karl-Franzens-University Graz Medical School, A-8036 Graz, Austria.

出版信息

Antimicrob Agents Chemother. 2003 Jan;47(1):371-4. doi: 10.1128/AAC.47.1.371-374.2003.

DOI:10.1128/AAC.47.1.371-374.2003
PMID:12499216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC148983/
Abstract

We investigated the distribution of the broad-spectrum antibiotic fosfomycin in infected soft tissue of patients with uncomplicated cellulitis of the lower extremities or diabetic foot infection using in vivo microdialysis. Our findings suggest that fosfomycin exhibits good and similar penetration into the fluid in the interstitial space in inflamed and noninflamed soft tissue in patients.

摘要

我们使用体内微透析技术，研究了广谱抗生素磷霉素在患有单纯性下肢蜂窝织炎或糖尿病足感染患者的感染性软组织中的分布情况。我们的研究结果表明，磷霉素在患者发炎和未发炎的软组织间质液中均表现出良好且相似的渗透能力。

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Distribution and antimicrobial activity of fosfomycin in the interstitial fluid of human soft tissues.磷霉素在人体软组织间质液中的分布及抗菌活性
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