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AcrR第45位氨基酸突变对临床和兽医源大肠杆菌分离株中acrB表达及环丙沙星耐药性的影响

Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates.

作者信息

Webber Mark A, Talukder Ashraf, Piddock Laura J V

机构信息

Antimicrobial Agents Research Group, Division of Immunity and Infection, The University of Birmingham, Edgbaston, UK.

出版信息

Antimicrob Agents Chemother. 2005 Oct;49(10):4390-2. doi: 10.1128/AAC.49.10.4390-4392.2005.

DOI:10.1128/AAC.49.10.4390-4392.2005
PMID:16189130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1251554/
Abstract

Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.

摘要

过表达acrB且AcrR第45位氨基酸发生替代的耐氟喹诺酮大肠杆菌分离株用野生型acrR进行了互补。互补导致对环丙沙星和溴化乙锭的敏感性增加，这表明AcrR第45位氨基酸的突变导致了环丙沙星耐药性。

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FEMS Microbiol Lett. 2004 Sep 1;238(1):267-72. doi: 10.1016/j.femsle.2004.07.046.
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Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: role in multiple antibiotic resistance.肠炎沙门氏菌鼠伤寒血清型中acrB、acrF、acrD、marA和soxS的表达：在多重抗生素耐药性中的作用
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Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.AcrR和ramA在新加坡临床肺炎克雷伯菌分离株对氟喹诺酮耐药中的作用
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Increased expression of the multidrug efflux genes acrAB occurs during slow growth of Escherichia coli.多药外排基因acrAB的表达增加发生在大肠杆菌生长缓慢期间。
FEMS Microbiol Lett. 2002 Jan 22;207(1):91-5. doi: 10.1111/j.1574-6968.2002.tb11034.x.
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Determination of minimum inhibitory concentrations.最低抑菌浓度的测定
J Antimicrob Chemother. 2001 Jul;48 Suppl 1:5-16. doi: 10.1093/jac/48.suppl_1.5.
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